Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10155
Title: Clinical phenotype associations with various types of anti-dsDNA antibodies in patients with recent onset of rheumatic symptoms. Results from a multicentre observational study.
Authors: Compagno, Michele
Rekvig, Ole P
Bengtsson, Anders A
Sturfelt, Gunnar
Heegaard, Niels H H
Jönsen, Andreas
Jacobsen, Rasmus Sleimann
Eilertsen, Gro Ø
Fenton, Christopher G
Truedsson, Lennart
Nossent, Johannes C
Jacobsen, Søren
Affiliation: Section of Rheumatology, Department of Clinical Sciences , Lund University , Lund , Sweden..
Department of Biochemistry , Institute of Medical Biology , University of Tromsø , Tromsø , Norway..
Section of Rheumatology, Department of Clinical Sciences , Lund University , Lund , Sweden..
Section of Rheumatology, Department of Clinical Sciences , Lund University , Lund , Sweden..
Statens Serum Institut , Copenhagen , Denmark..
Section of Rheumatology, Department of Clinical Sciences , Lund University , Lund , Sweden..
Department of Rheumatology , Rigshospitalet , Copenhagen University Hospital , Copenhagen , Denmark..
Bone and Joint Research Group, Department of Clinical Medicine, Faculty of Health Science , University of Tromsø , Tromsø , Norway..
Department of Biochemistry , Institute of Medical Biology , University of Tromsø , Tromsø , Norway..
Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology , Lund University , Lund , Sweden..
Bone and Joint Research Group, Department of Clinical Medicine, Faculty of Health Science , University of Tromsø , Tromsø , Norway ; Division of Medicine, Rheumatology Section , Royal Darwin Hospital , Darwin, Northern Territory , Australia..
Department of Rheumatology , Rigshospitalet , Copenhagen University Hospital , Copenhagen , Denmark..
Issue Date: 2014
Citation: Lupus science & medicine 2014; 1(1): e000007
Abstract: Despite anti-dsDNA antibodies constitute a wide range of specificities, they are considered as the hallmark for systemic lupus erythematosus (SLE). To identify clinical phenotypes associated with anti-dsDNA antibodies, independently of any clinical diagnoses. Patients with recent onset of any rheumatic symptoms were screened for antinuclear antibodies (ANA). All ANA-positive and matching ANA-negative patients were examined, and their clinical phenotypes were registered, using a systematic chart formulated after consensus between the participating centres. All patients were tested for different anti-dsDNA antibody specificities with assays habitually used in each participating laboratory. Crithidia Luciliae Immuno Fluorescence Test (CLIFT) was performed three times (with two different commercial kits); solid and solution phase ELISA were performed four times. Associations between clinical phenotypes and results of anti-dsDNA assays were evaluated by linear regression analysis (LRA) and principal component analysis (PCA). Totally, 292 ANA-positive and 292 matching ANA-negative patients were included in the study. A full dataset for statistical analysis was obtained in 547 patients. Anti-dsDNA antibodies were most frequently detected by ELISA. LRA showed that overall positivity of anti-dsDNA antibodies was associated with proteinuria and pleuritis. Alopecia was significantly associated only with CLIFT-positivity. Besides confirming the same findings, PCA showed that combined positivity of CLIFT and ELISA was also associated with lymphopenia. Our results show that different anti-dsDNA antibody specificities are associated with nephropathy, pleuritis, alopecia and lymphopenia, regardless of the diagnosis. It may challenge the importance of anti-dsDNA antibodies as a diagnostic hallmark for SLE.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10155
DOI: 10.1136/lupus-2013-000007
ISSN: 2053-8790
Type: Journal Article
Subjects: Autoantibodies
Autoimmune Diseases
Autoimmunity
Lupus Nephritis
Systemic Lupus Erythematosus
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