Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10155
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dc.contributor.authorCompagno, Michele-
dc.contributor.authorRekvig, Ole P-
dc.contributor.authorBengtsson, Anders A-
dc.contributor.authorSturfelt, Gunnar-
dc.contributor.authorHeegaard, Niels H H-
dc.contributor.authorJönsen, Andreas-
dc.contributor.authorJacobsen, Rasmus Sleimann-
dc.contributor.authorEilertsen, Gro Ø-
dc.contributor.authorFenton, Christopher G-
dc.contributor.authorTruedsson, Lennart-
dc.contributor.authorNossent, Johannes C-
dc.contributor.authorJacobsen, Søren-
dc.date2014-
dc.date.accessioned2018-05-15T23:01:08Z-
dc.date.accessioned2019-06-29T00:36:44Z-
dc.date.available2018-05-15T23:01:08Z-
dc.date.available2019-06-29T00:36:44Z-
dc.date.issued2014-
dc.identifier.citationLupus science & medicine 2014; 1(1): e000007-
dc.identifier.issn2053-8790-
dc.identifier.urihttp://docs.prosentient.com.au/prosentientjspui/handle/1/10155-
dc.description.abstractDespite anti-dsDNA antibodies constitute a wide range of specificities, they are considered as the hallmark for systemic lupus erythematosus (SLE). To identify clinical phenotypes associated with anti-dsDNA antibodies, independently of any clinical diagnoses. Patients with recent onset of any rheumatic symptoms were screened for antinuclear antibodies (ANA). All ANA-positive and matching ANA-negative patients were examined, and their clinical phenotypes were registered, using a systematic chart formulated after consensus between the participating centres. All patients were tested for different anti-dsDNA antibody specificities with assays habitually used in each participating laboratory. Crithidia Luciliae Immuno Fluorescence Test (CLIFT) was performed three times (with two different commercial kits); solid and solution phase ELISA were performed four times. Associations between clinical phenotypes and results of anti-dsDNA assays were evaluated by linear regression analysis (LRA) and principal component analysis (PCA). Totally, 292 ANA-positive and 292 matching ANA-negative patients were included in the study. A full dataset for statistical analysis was obtained in 547 patients. Anti-dsDNA antibodies were most frequently detected by ELISA. LRA showed that overall positivity of anti-dsDNA antibodies was associated with proteinuria and pleuritis. Alopecia was significantly associated only with CLIFT-positivity. Besides confirming the same findings, PCA showed that combined positivity of CLIFT and ELISA was also associated with lymphopenia. Our results show that different anti-dsDNA antibody specificities are associated with nephropathy, pleuritis, alopecia and lymphopenia, regardless of the diagnosis. It may challenge the importance of anti-dsDNA antibodies as a diagnostic hallmark for SLE.-
dc.language.isoeng-
dc.subjectAutoantibodies-
dc.subjectAutoimmune Diseases-
dc.subjectAutoimmunity-
dc.subjectLupus Nephritis-
dc.subjectSystemic Lupus Erythematosus-
dc.titleClinical phenotype associations with various types of anti-dsDNA antibodies in patients with recent onset of rheumatic symptoms. Results from a multicentre observational study.-
dc.typeJournal Article-
dc.identifier.doi10.1136/lupus-2013-000007-
dc.identifier.journaltitleLupus science & medicine-
dc.identifier.pubmedurihttps://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/25396058-
dc.identifier.pubmedidhttps://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/25396058-
dc.identifier.affiliationSection of Rheumatology, Department of Clinical Sciences , Lund University , Lund , Sweden..-
dc.identifier.affiliationDepartment of Biochemistry , Institute of Medical Biology , University of Tromsø , Tromsø , Norway..-
dc.identifier.affiliationSection of Rheumatology, Department of Clinical Sciences , Lund University , Lund , Sweden..-
dc.identifier.affiliationSection of Rheumatology, Department of Clinical Sciences , Lund University , Lund , Sweden..-
dc.identifier.affiliationStatens Serum Institut , Copenhagen , Denmark..-
dc.identifier.affiliationSection of Rheumatology, Department of Clinical Sciences , Lund University , Lund , Sweden..-
dc.identifier.affiliationDepartment of Rheumatology , Rigshospitalet , Copenhagen University Hospital , Copenhagen , Denmark..-
dc.identifier.affiliationBone and Joint Research Group, Department of Clinical Medicine, Faculty of Health Science , University of Tromsø , Tromsø , Norway..-
dc.identifier.affiliationDepartment of Biochemistry , Institute of Medical Biology , University of Tromsø , Tromsø , Norway..-
dc.identifier.affiliationDepartment of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology , Lund University , Lund , Sweden..-
dc.identifier.affiliationBone and Joint Research Group, Department of Clinical Medicine, Faculty of Health Science , University of Tromsø , Tromsø , Norway ; Division of Medicine, Rheumatology Section , Royal Darwin Hospital , Darwin, Northern Territory , Australia..-
dc.identifier.affiliationDepartment of Rheumatology , Rigshospitalet , Copenhagen University Hospital , Copenhagen , Denmark..-
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