Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10160
Title: The national incidence and clinical picture of SLE in children in Australia - a report from the Australian Paediatric Surveillance Unit.
Authors: Mackie, F E
Kainer, G
Adib, N
Boros, C
Elliott, E J
Fahy, R
Munro, J
Murray, K
Rosenberg, A
Wainstein, B
Ziegler, J B
Singh-Grewal, D
Affiliation: Department of Nephrology, Sydney Children's Hospital and University of NSW, Australia f.mackie@unsw.edu.au..
Department of Nephrology, Sydney Children's Hospital and University of NSW, Australia..
Queensland Paediatric Rheumatology Services, Australia..
Discipline of Paediatrics, University of Adelaide and Rheumatology, Women and Children's Health Network, Adelaide, Australia..
Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Australia..
Department of Paediatrics, Alice Springs Hospital, Australia..
Rheumatology Unit, Royal Children's Hospital, Melbourne, Australia..
Princess Margaret Hospital for Children, Perth, Australia..
Department of Nephrology, Sydney Children's Hospital and University of NSW, Australia..
Department of Immunology, Sydney Children's Hospital, Australia..
Department of Immunology, Sydney Children's Hospital, Australia..
Department of Rheumatology, Sydney Children's Hospital Network, Australia..
Issue Date: Jan-2015
Citation: Lupus 2015-01; 24(1): 66-73
Abstract: The objectives of this paper are to prospectively determine the incidence of paediatric systemic lupus erythematosus (pSLE) in Australia as well as describe the demographics, clinical presentation and one-year outcome. Newly diagnosed cases of pSLE were ascertained prospectively from October 2009 to October 2011 through the Australian Paediatric Surveillance Unit (a national monthly surveillance scheme for notification of childhood rare diseases) as well as national subspecialty groups. Questionnaires were sent to notifying physicians at presentation and at one year. The annual incidence rate was 0.32 per 10(5) children aged less than 16 years. The incidence was significantly higher in children of Asian or Australian Aboriginal and Torres Strait Islander parents. Approximately one-third of children underwent a renal biopsy at presentation and 7% required dialysis initially although only one child had end-stage kidney disease (ESKD) at one-year follow-up. The incidence of pSLE in Australia is comparable to that worldwide with a significantly higher incidence seen in children of Asian and Australian Aboriginal and Torres Strait Islander backgrounds. Renal involvement is common but progression to ESKD, at least in the short term, is rare.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10160
DOI: 10.1177/0961203314552118
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: Australian Aboriginal and Torres Strait Islanders
Systemic lupus erythematosus
incidence
lupus nephritis
Adolescent
Age of Onset
Antibodies, Antinuclear
Asian Continental Ancestry Group
Australia
Child
Child, Preschool
Disease Progression
Female
Follow-Up Studies
Humans
Incidence
Lupus Erythematosus, Systemic
Lupus Nephritis
Male
Oceanic Ancestry Group
Prospective Studies
Proteinuria
Rheumatic Fever
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