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Title: Peritonitis due to Cunninghamella bertholletiae in a patient undergoing continuous ambulatory peritoneal dialysis.
Authors: Pimentel, Jason D
Dreyer, Gavin
Lum, Gary D
Affiliation: Northern Territory Government Pathology Service, Royal Darwin Hospital, PO Box 41326, Casuarina, NT 0811, Australia.
Issue Date: Jan-2006
Citation: Journal of medical microbiology 2006-01; 55(Pt 1): 115-8
Abstract: Peritoneal dialysis-associated peritonitis due to fungi of the class Zygomycetes occurs very rarely. A case of fungal continuous ambulatory peritoneal dialysis peritonitis due to Cunninghamella bertholletiae is reported in a 39-year-old Aboriginal woman with end-stage renal failure and diabetes mellitus. This isolate was found to be resistant in vitro to amphotericin B, 5-fluorocytosine, fluconazole, itraconazole, ketoconazole and voriconazole. However, this patient was successfully treated with voriconazole and removal of the Tenckhoff dialysis catheter. Zygomycoses are an emerging threat among immunocompromised patients, including those with chronic renal failure. Zygomycosis due to C. bertholletiae is frequently fatal and is often non-responsive to systemic antifungal therapy. This is believed to be the first reported case of C. bertholletiae causing peritonitis in humans and one of the minority of cases involving this organism with a successful outcome.
DOI: 10.1099/jmm.0.46202-0
ISSN: 0022-2615
Type: Case Reports
Journal Article
Subjects: Adult
Peritoneal Dialysis, Continuous Ambulatory
Appears in Collections:NT Health digital library

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