Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10220
Title: C-reactive protein concentrations are very high and more stable over time than the traditional vascular risk factors total cholesterol and systolic blood pressure in an Australian aboriginal cohort.
Authors: Shemesh, Tomer
Rowley, Kevin G
Jenkins, Alicia J
Best, James D
O'Dea, Kerin
Affiliation: Menzies School of Health Research, John Mathews Building, Royal Darwin Hospital, Darwin, NT, Australia..
Issue Date: Feb-2009
Citation: Clinical chemistry 2009-02; 55(2): 336-41
Abstract: Stability of circulating high-sensitivity C-reactive protein (hsCRP) concentrations has implications for its utility in assessing cardiovascular disease (CVD) risk. We sought to determine hsCRP reproducibility in an indigenous Australian cohort with a view to use hsCRP as a marker of future CVD in community-based risk-factor screenings. Seventy people living in a community on the northern coast of Australia participated in 2 risk-factor screenings over a median (interquartile range) follow-up time of 829 (814-1001) days. hsCRP was measured by high-sensitivity nephelometry. Geometric mean hsCRP concentrations at baseline and follow-up were 4.5 and 5.1 mg/L, respectively (P = 0.220), and Pearson product-moment correlation was 0.775. The proportion of people at high CVD risk (hsCRP >3.0 mg/L) at baseline was 67.1% and remained consistently high (68.6%) at follow-up. Linear regression analysis for follow-up hsCRP as a function of baseline hsCRP, sex, and differences in total and regional body fatness showed that baseline hsCRP was the single predictor in the model, accounting for 63.9% of the total variance in follow-up hsCRP (P(model) < 0.001). Prevalence agreement (95% CI) between baseline and follow-up for the hsCRP >3.0 mg/L category was 84% (73%-92%) (P(McNemar) = not significant), and kappa coefficient was fair (0.64, compared with 0.31 for systolic blood pressure > or =140 mmHg and 0.43 for total cholesterol > or =5.5 mmol/L). hsCRP concentrations remained consistently reproducible over time across a wide concentration range in an Aboriginal cohort. Correlations between concentrations over time were better than for other traditional CVD risk factors. hsCRP concentration has potential as a marker of future CVD risk.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10220
DOI: 10.1373/clinchem.2008.115360
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: Biomarkers
Blood Pressure
C-Reactive Protein
Cardiovascular Diseases
Cholesterol
Cohort Studies
Follow-Up Studies
Humans
Linear Models
Northern Territory
Population Surveillance
Risk Factors
Oceanic Ancestry Group
Appears in Collections:NT Health digital library

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