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dc.contributor.authorShemesh, Tomer-
dc.contributor.authorRowley, Kevin G-
dc.contributor.authorJenkins, Alicia J-
dc.contributor.authorBest, James D-
dc.contributor.authorO'Dea, Kerin-
dc.identifier.citationClinical chemistry 2009-02; 55(2): 336-41-
dc.description.abstractStability of circulating high-sensitivity C-reactive protein (hsCRP) concentrations has implications for its utility in assessing cardiovascular disease (CVD) risk. We sought to determine hsCRP reproducibility in an indigenous Australian cohort with a view to use hsCRP as a marker of future CVD in community-based risk-factor screenings. Seventy people living in a community on the northern coast of Australia participated in 2 risk-factor screenings over a median (interquartile range) follow-up time of 829 (814-1001) days. hsCRP was measured by high-sensitivity nephelometry. Geometric mean hsCRP concentrations at baseline and follow-up were 4.5 and 5.1 mg/L, respectively (P = 0.220), and Pearson product-moment correlation was 0.775. The proportion of people at high CVD risk (hsCRP >3.0 mg/L) at baseline was 67.1% and remained consistently high (68.6%) at follow-up. Linear regression analysis for follow-up hsCRP as a function of baseline hsCRP, sex, and differences in total and regional body fatness showed that baseline hsCRP was the single predictor in the model, accounting for 63.9% of the total variance in follow-up hsCRP (P(model) < 0.001). Prevalence agreement (95% CI) between baseline and follow-up for the hsCRP >3.0 mg/L category was 84% (73%-92%) (P(McNemar) = not significant), and kappa coefficient was fair (0.64, compared with 0.31 for systolic blood pressure > or =140 mmHg and 0.43 for total cholesterol > or =5.5 mmol/L). hsCRP concentrations remained consistently reproducible over time across a wide concentration range in an Aboriginal cohort. Correlations between concentrations over time were better than for other traditional CVD risk factors. hsCRP concentration has potential as a marker of future CVD risk.-
dc.subject.meshBlood Pressure-
dc.subject.meshC-Reactive Protein-
dc.subject.meshCardiovascular Diseases-
dc.subject.meshCohort Studies-
dc.subject.meshFollow-Up Studies-
dc.subject.meshLinear Models-
dc.subject.meshNorthern Territory-
dc.subject.meshPopulation Surveillance-
dc.subject.meshRisk Factors-
dc.subject.meshOceanic Ancestry Group-
dc.titleC-reactive protein concentrations are very high and more stable over time than the traditional vascular risk factors total cholesterol and systolic blood pressure in an Australian aboriginal cohort.-
dc.typeJournal Article-
dc.typeResearch Support, Non-U.S. Gov't-
dc.identifier.journaltitleClinical chemistry-
dc.identifier.affiliationMenzies School of Health Research, John Mathews Building, Royal Darwin Hospital, Darwin, NT, Australia..-
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