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Title: Influenza epidemiology, vaccine coverage and vaccine effectiveness in sentinel Australian hospitals in 2012: the Influenza Complications Alert Network (FluCAN).
Authors: Cheng, Allen C
Brown, Simon
Waterer, Grant
Holmes, Mark
Senenayake, Sanjaya
Friedman, N Deborah
Hewagama, Saliya
Simpson, Graham
Wark, Peter
Upham, John
Korman, Tony
Dwyer, Dominic
Wood-Baker, Richard
Irving, Louis
Bowler, Simon
Kotsimbos, Tom
Kelly, Paul
Affiliation: Alfred Health; Monash University, Melbourne, Victoria..
University of Western Australia, Perth, Western Australia; Royal Perth Hospital, Perth, Western Australia..
University of Western Australia, Perth, Western Australia; Royal Perth Hospital, Perth, Western Australia..
Royal Adelaide Hospital, Adelaide, South Australia; University of Adelaide, Adelaide, South Australia..
Australian National University, Acton, Australian Capital Territory; The Canberra Hospital, Garran, Australian Capital Territory..
Barwon Health, Geelong, Victoria..
Alice Springs Hospital, Alice Springs, Northern Territory..
Cairns Base Hospital, Cairns, Queensland..
University of Newcastle, Newcastle, New South Wales; John Hunter Hospital, Newcastle, New South Wales..
Princess Alexandra Hospital, Brisbane, Queensland; University of Queensland, Brisbane, Queensland..
Monash Medical Centre, Melbourne, Victoria..
University of Sydney, Sydney, New South Wales; Westmead Hospital, Sydney, New South Wales..
University of Tasmania, Hobart, Tasmania..
Royal Melbourne Hospital, Melbourne, Victoria; University of Melbourne, Melbourne, Victoria..
Mater Hospitals, Brisbane, Queensland..
Alfred Health; Monash University, Melbourne, Victoria..
ACT Health Directorate, Canberra, Australian Capital Territory..
Issue Date: 30-Sep-2013
Citation: Communicable diseases intelligence quarterly report 2013-09-30; 37(3): E246-52
Abstract: Influenza is mostly a mild, self-limiting infection and severe infection requiring hospitalisation is uncommon. Immunisation aims to reduce serious morbidity and mortality. The Influenza Complications Alert Network (FluCAN) is a sentinel hospital-based surveillance program that operates at 15 sites across all states and territories in Australia. This study reports on the epidemiology of hospitalisation with confirmed influenza, estimate vaccine coverage and influenza vaccine protection against hospitalisation with influenza during the 2012 influenza season. In this observational study, cases were defined as patients admitted to one of the sentinel hospitals with influenza confirmed by nucleic acid detection. Controls were patients who had acute respiratory illnesses who were test-negative for influenza. Vaccine effectiveness was estimated as 1┬áminus the odds ratio of vaccination in case patients compared with control patients, after adjusting for known confounders. During the period 9 April to 31 October 2012, 1,231 patients were admitted with confirmed influenza at the 15 FluCAN sentinel hospitals. Of these, 47% were more than 65 years of age, 8% were Indigenous Australians, 3% were pregnant and 76% had chronic co-morbidities. Influenza A was detected in 83% of patients. Vaccination coverage was calculated from the vaccination status of 1,216 test negative controls and was estimated at 77% in patients 65 years or over and 61% in patients with chronic comorbidities. Vaccination effectiveness was estimated at 41% (95% CI: 28%, 51%, P<0.001). Vaccine coverage was incomplete in at-risk groups, particularly non-elderly patients with medical comorbidities. The study results suggest that the seasonal influenza vaccine was moderately protective against hospitalisation with influenza during the 2012 season.
ISSN: 1447-4514
Type: Historical Article
Journal Article
Subjects: Adolescent
Aged, 80 and over
History, 21st Century
Influenza Vaccines
Influenza, Human
Middle Aged
Risk Factors
Young Adult
Cross Infection
Sentinel Surveillance
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