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Title: APRIL levels strongly correlate with IL-17 in systemic lupus erythematosus.
Authors: Eilertsen, G Ø
Nossent, J C
Affiliation: Bone and Joint Research Group, Department of Clinical Medicine, Faculty of Health Science, University of Tromsø, Norway
Bone and Joint Research Group, Department of Clinical Medicine, Faculty of Health Science, University of Tromsø, Norway Rheumatology Section, Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia..
Issue Date: Nov-2014
Citation: Lupus 2014-11; 23(13): 1383-91
Abstract: Activated self-reactive B cells play an important part in systemic lupus erythematosus (SLE). A proliferation-inducing ligand (APRIL) and B cell-activating factor (BAFF) are B-cell specific stimulators, but activate B cells through different receptors. We investigated the reciprocal association between serum APRIL (s-APRIL), serum BAFF (s-BAFF) and immunological and clinical findings in SLE patients. A cross-sectional case-control study was performed in 100 SLE patients (87% female, age 49 years, disease duration 12 years). APRIL and BAFF levels were measured by sandwich ELISA, compared with healthy controls and correlated with autoantibody, cytokine (IL-6 and IL-17) and clinical findings through nonparametric and multivariate regression analyses. Both median s-APRIL (478 vs. 0 pg/ml, p = 0.01) and s-BAFF (1720 vs. 0.9 pg/ml, p < 0.001) were higher in SLE patients than controls. Increased s-BAFF was observed in 86% of patients, while s-APRIL was increased only in 17% (p < 0.01). S-APRIL correlated with s-BAFF in controls (p = 0.04), but not in SLE (p = 0.8). Increased s-APRIL was strongly and independently associated with IL-17 activation (p < 0.001), while increased s-BAFF levels were associated with anti-nucleosome antibody presence (p = 0.001). Disease activity and organ damage were associated with s-BAFF but not s-APRIL. While both s-BAFF and s-APRIL levels are elevated in SLE patients, they reflect different immunologic and clinical pathways. The strong association between s-APRIL and IL-17 activation supports a role for Th17 helper cells in B cell activation in SLE.
DOI: 10.1177/0961203314543914
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: B-lymphocyte activating factor
a proliferation-inducing ligand
systemic lupus erythematosus
B-Cell Activating Factor
Case-Control Studies
Cross-Sectional Studies
Immunologic Factors
Lupus Erythematosus, Systemic
Middle Aged
Severity of Illness Index
Tumor Necrosis Factor Ligand Superfamily Member 13
Appears in Collections:NT Health digital library

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