Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10306
Title: APRIL levels strongly correlate with IL-17 in systemic lupus erythematosus.
Authors: Eilertsen, G Ø
Nossent, J C
Affiliation: Bone and Joint Research Group, Department of Clinical Medicine, Faculty of Health Science, University of Tromsø, Norway gro.eilertsen@uit.no..
Bone and Joint Research Group, Department of Clinical Medicine, Faculty of Health Science, University of Tromsø, Norway Rheumatology Section, Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia..
Issue Date: Nov-2014
Citation: Lupus 2014-11; 23(13): 1383-91
Abstract: Activated self-reactive B cells play an important part in systemic lupus erythematosus (SLE). A proliferation-inducing ligand (APRIL) and B cell-activating factor (BAFF) are B-cell specific stimulators, but activate B cells through different receptors. We investigated the reciprocal association between serum APRIL (s-APRIL), serum BAFF (s-BAFF) and immunological and clinical findings in SLE patients. A cross-sectional case-control study was performed in 100 SLE patients (87% female, age 49 years, disease duration 12 years). APRIL and BAFF levels were measured by sandwich ELISA, compared with healthy controls and correlated with autoantibody, cytokine (IL-6 and IL-17) and clinical findings through nonparametric and multivariate regression analyses. Both median s-APRIL (478 vs. 0 pg/ml, p = 0.01) and s-BAFF (1720 vs. 0.9 pg/ml, p < 0.001) were higher in SLE patients than controls. Increased s-BAFF was observed in 86% of patients, while s-APRIL was increased only in 17% (p < 0.01). S-APRIL correlated with s-BAFF in controls (p = 0.04), but not in SLE (p = 0.8). Increased s-APRIL was strongly and independently associated with IL-17 activation (p < 0.001), while increased s-BAFF levels were associated with anti-nucleosome antibody presence (p = 0.001). Disease activity and organ damage were associated with s-BAFF but not s-APRIL. While both s-BAFF and s-APRIL levels are elevated in SLE patients, they reflect different immunologic and clinical pathways. The strong association between s-APRIL and IL-17 activation supports a role for Th17 helper cells in B cell activation in SLE.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10306
DOI: 10.1177/0961203314543914
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: B-lymphocyte activating factor
a proliferation-inducing ligand
autoantibodies
cytokines
interleukin-17
systemic lupus erythematosus
Autoantibodies
B-Cell Activating Factor
Case-Control Studies
Cross-Sectional Studies
Female
Humans
Immunologic Factors
Interleukin-17
Lupus Erythematosus, Systemic
Male
Middle Aged
Severity of Illness Index
Tumor Necrosis Factor Ligand Superfamily Member 13
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