Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10323
Title: Emerging pneumococcal carriage serotypes in a high-risk population receiving universal 7-valent pneumococcal conjugate vaccine and 23-valent polysaccharide vaccine since 2001.
Authors: Leach, Amanda J
Morris, Peter S
McCallum, Gabrielle B
Wilson, Cate A
Stubbs, Liz
Beissbarth, Jemima
Jacups, Susan
Hare, Kim
Smith-Vaughan, Heidi C
Affiliation: Menzies School of Health Research, John Mathews Building (Bldg58), Royal Darwin Hospital, Rocklands Drive, Tiwi, Northern Territory, Australia. amanda.leach@menzies.edu.au.
Issue Date: 4-Aug-2009
Citation: BMC infectious diseases 2009-08-04; 9: 121
Abstract: In Australia in June 2001, a unique pneumococcal vaccine schedule commenced for Indigenous infants; seven-valent pneumococcal conjugate vaccine (7PCV) given at 2, 4, and 6 months of age and 23-valent pneumococcal polysaccharide vaccine (23PPV) at 18 months of age. This study presents carriage serotypes following this schedule. We conducted cross sectional surveys of pneumococcal carriage in Aboriginal children 0 to 6 years of age living in remote Aboriginal communities (RACs) in 2003 and 2005. Nasal secretions were collected and processed according to published methods. 902 children (mean age 25 months) living in 29 communities in 2003 and 818 children (mean age 35 months) in 17 communities in 2005 were enrolled. 87% children in 2003 and 96% in 2005 had received two or more doses of 7PCV. From 2003 to 2005, pneumococcal carriage was reduced from 82% to 76% and reductions were apparent in all age groups; 7PCV-type carriage was reduced from 11% to 8%, and 23PPV-non-7PCV-type carriage from 31% to 25% respectively. Thus non-23PPV-type carriage increased from 57% to 67%. All these changes were statistically significant, as were changes for some specific serotypes. Shifts could not be attributed to vaccination alone. The top 10 of 40 serotypes identified were (in descending order) 16F, 19A, 11A, 6C, 23B, 19F, 6A, 35B, 6B, 10A and 35B. Carriage of penicillin non-susceptible (MIC > or = 0.12 microg/mL) strains (15% overall) was detected in serotypes (descending order) 19A, 19F, 6B, 16F, 11A, 9V, 23B, and in 4 additional serotypes. Carriage of azithromycin resistant (MIC > or = 2 microg/mL) strains (5% overall), was detected in serotypes (descending order) 23B, 17F, 9N, 6B, 6A, 11A, 23F, and in 10 additional serotypes including 6C. Pneumococcal carriage remains high (approximately80%) in this vaccinated population. Uptake of both pneumococcal vaccines increased, and carriage was reduced between 2003 and 2005. Predominant serotypes in combined years were 16F, 19A, 11A, 6C and 23B. Antimicrobial non-susceptibility was detected in these and 17 additional serotypes. Shifts in serotype-specific carriage suggest a need more research to clarify the association between pneumococcal vaccination and carriage at the serotype level.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10323
DOI: 10.1186/1471-2334-9-121
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: Australia
Carrier State
Child
Child, Preschool
Cross-Sectional Studies
Drug Resistance, Bacterial
Female
Heptavalent Pneumococcal Conjugate Vaccine
Humans
Immunization Programs
Infant
Male
Nasopharynx
Pneumococcal Vaccines
Serotyping
Streptococcus pneumoniae
Appears in Collections:NT Health digital library

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.