Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10402
Title: Global and regional dissemination and evolution of Burkholderia pseudomallei.
Authors: Chewapreecha, Claire
Holden, Matthew T G
Vehkala, Minna
Välimäki, Niko
Yang, Zhirong
Harris, Simon R
Mather, Alison E
Tuanyok, Apichai
De Smet, Birgit
Le Hello, Simon
Bizet, Chantal
Mayo, Mark
Wuthiekanun, Vanaporn
Limmathurotsakul, Direk
Phetsouvanh, Rattanaphone
Spratt, Brian G
Corander, Jukka
Keim, Paul
Dougan, Gordon
Dance, David A B
Currie, Bart J
Parkhill, Julian
Peacock, Sharon J
Affiliation: Department of Medicine, University of Cambridge, CB2 0QQ, UK.. Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.. Bioinformatics and Systems Biology Program, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, 10140 Bangkok, Thailand..
Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.. School of Medicine, University of St Andrew, KY16 9AJ, UK..
Department of Mathematics and Statistics, University of Helsinki 00100, Finland..
Department of Medical and Clinical Genetics, Genome-Scale Biology Research Program, University of Helsinki 00100, Finland..
Department of Mathematics and Statistics, University of Helsinki 00100, Finland..
Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK..
Department of Veterinary Medicine, University of Cambridge, CB3 0ES, UK..
Emerging Pathogens Institute, University of Florida, Florida 32611, USA..
Department of Clinical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium.. Laboratory of Microbiology, Faculty of Sciences, Ghent University, 9000 Belgium..
Department of Infection and Epidemiology, Enteric bacteria pathogen Unit, Institut Pasteur, 75015 Paris, France..
Department of Microbiology, Collection of Institut Pasteur, Institut Pasteur, 75015 Paris, France..
Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University and Royal Darwin Hospital, Darwin, Northern Territory 0811 Australia..
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 10400 Bangkok, Thailand..
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 10400 Bangkok, Thailand.. Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, 10400 Bangkok, Thailand.. Centre for Tropical Medicine &Global Health, University of Oxford, OX3 7FZ, UK..
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR..
Department of Infectious Disease Epidemiology, Imperial College, SW7 2AZ, UK..
Department of Mathematics and Statistics, University of Helsinki 00100, Finland.. Department of Biostatistics, University of Oslo, 0313 Oslo, Norway..
Center for Microbial Genetics and Genomics, Northern Arizona University, Arizona 86011-4073, USA..
Department of Medicine, University of Cambridge, CB2 0QQ, UK.. Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK..
Centre for Tropical Medicine &Global Health, University of Oxford, OX3 7FZ, UK.. Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.. London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK..
Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University and Royal Darwin Hospital, Darwin, Northern Territory 0811 Australia..
Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK..
Department of Medicine, University of Cambridge, CB2 0QQ, UK.. Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.. London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK..
Issue Date: 23-Jan-2017
Citation: Nature microbiology 2017-01-23; 2: 16263
Abstract: The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10402
DOI: 10.1038/nmicrobiol.2016.263
ORCID: http://orcid.org/0000-0002-4958-2166
http://orcid.org/0000-0003-1512-6194
http://orcid.org/0000-0001-9189-7244
http://orcid.org/0000-0002-7069-5958
Type: Journal Article
Appears in Collections:NT Health digital library

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