Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10410
Title: Plasmodium knowlesi malaria in Sabah, Malaysia, 2015-2017: ongoing increase in incidence despite near-elimination of the human-only Plasmodium species.
Authors: Cooper, Daniel J
Rajahram, Giri S
William, Timothy
Jelip, Jenarun
Mohammad, Rashidah
Benedict, Joseph
Alaza, Danshy A
Malacova, Eva
Yeo, Tsin W
Grigg, Matthew J
Anstey, Nicholas M
Barber, Bridget E
Affiliation: Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia.. Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia..
Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia.. Clinical Research Centre - Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Ministry of Health, Malaysia.. Sabah Department of Health, Kota Kinabalu, Sabah, Ministry of Health, Malaysia..
Gleneagles Kota Kinabalu Hospital, Sabah, Malaysia..
Malaysian Ministry of Health, Kuala Lumpur, Malaysia..
Sabah Department of Health, Kota Kinabalu, Sabah, Ministry of Health, Malaysia..
Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia..
Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia..
QIMR Berghofer Institute of Medical Research, Brisbane, Australia..
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore..
Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia.. Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia..
Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia.. Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia..
Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia.. Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia.. QIMR Berghofer Institute of Medical Research, Brisbane, Australia..
Issue Date: 19-Mar-2019
Citation: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2019-03-19
Abstract: Malaysia aims to eliminate malaria by 2020. However, while cases of Plasmodium falciparum and P. vivax have fallen substantially, the incidence of zoonotic malaria from P. knowlesi continues to increase, presenting a major challenge to regional malaria control efforts. Here we report incidence of all Plasmodium species in Sabah, including zoonotic P. knowlesi, during 2015-2017. Microscopy-based malaria notification data and PCR results were obtained from the Sabah Department of Health and State Public Health Laboratory, respectively, from January 2015 to December 2017. From January 2016 this was complemented by a state-wide prospective hospital surveillance study. Databases were matched, and species was determined by PCR, or microscopy if PCR was not available. A total of 3867 malaria cases were recorded between 2015 and 2017, with PCR performed in 93%. Using PCR results, and microscopy if PCR was unavailable, P. knowlesi accounted for 817 (80%), 677 (88%), and 2030 (98%) malaria cases in 2015, 2016, and 2017, respectively. P. falciparum accounted for 110 (11%), 45 (6%), and 23 (1%) cases, and P. vivax 61 (6%), 17 (2%), and 8 (0.4%) cases, respectively. Of those with P. knowlesi, median age was 35 (IQR 24 - 47) years, and 85% were male. Malaysia is approaching elimination of the human-only Plasmodium species. However, the ongoing increase in P. knowlesi incidence presents a major challenge to malaria control and warrants increased focus on knowlesi-specific prevention activities. Wider molecular surveillance in surrounding countries is required.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10410
DOI: 10.1093/cid/ciz237
Type: Journal Article
Subjects: Elimination
Epidemiology
Incidence
Knowlesi
Malaria
Appears in Collections:NT Health digital library

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.