Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10436
Title: Osteomyelitis and septic arthritis from infection with Burkholderia pseudomallei: A 20-year prospective melioidosis study from northern Australia.
Authors: Morse, Levi P
Smith, Jonathan
Mehta, Janak
Ward, Linda
Cheng, Allen C
Currie, Bart J
Affiliation: Department of Orthopaedics and Trauma, Royal Darwin Hospital, Casuarina, NT 0811, Australia..
Department of Orthopaedics and Trauma, Royal Darwin Hospital, Casuarina, NT 0811, Australia..
Department of Orthopaedics and Trauma, Royal Darwin Hospital, Casuarina, NT 0811, Australia..
Menzies School of Health Research, Casuarina, NT 0811, Australia..
Menzies School of Health Research, Casuarina, NT 0811, Australia..
Department of Orthopaedics and Trauma, Royal Darwin Hospital, Casuarina, NT 0811, Australia ; Menzies School of Health Research, Casuarina, NT 0811, Australia..
Issue Date: 2013
Citation: Journal of orthopaedics 2013; 10(2): 86-91
Abstract: The gram-negative organism, Burkholderia pseudomallei, is responsible for the disease melioidosis. Septic arthritis and osteomyelitis due to B. pseudomallei are rare but recognised presentations of the disease. A prospective database of all cases of melioidosis in the Northern Territory of Australia has been kept since October 1989. Entries to April 2009 were reviewed and cases involving bone and/or joint were investigated. We also present in detail the case reports of 3 presentations of bone and joint melioidosis. There were 536 presentations of melioidosis during the 20-year study period. Amongst these, there were 13 patients with primary septic arthritis and 7 cases of primary osteomyelitis. Septic arthritis and osteomyelitis were secondary to primary melioidosis elsewhere in 14 and 7 patients respectively. Melioidosis patients with bone/joint involvement were more likely to be Indigenous (p = 0.006) and female (p = 0.023) compared to patients with other presentations of disease. Timely microbiological diagnosis and prompt treatment of melioidosis involving bone and/or joint with appropriate intravenous antibiotics is important, as is adequate surgical drainage and debridement where indicated. A subsequent protracted course of antibiotic eradication therapy is important to avoid relapse of disease.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10436
DOI: 10.1016/j.jor.2013.04.001
ISSN: 0972-978X
Type: Journal Article
Subjects: Bone
Infection
Melioidosis
Osteomyelitis
Septic arthritis
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