Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10447
Title: Adjunctive granulocyte colony-stimulating factor for treatment of septic shock due to melioidosis.
Authors: Cheng, Allen C
Stephens, Dianne P
Anstey, Nicholas M
Currie, Bart J
Affiliation: Menzies School of Health Research, Royal Darwin Hospital, Northern Territory Clinical School, Flinders University, Casuarina NT, Darwin, Australia. allenc@menzies.edu.au.
Issue Date: 1-Jan-2004
Citation: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004-01-01; 38(1): 32-7
Abstract: Melioidosis, caused by the intracellular pathogen Burkholderia pseudomallei, is endemic in northern Australia and Southeast Asia. Risk factors for this infection have also been associated with functional neutrophil defects. Because of this, granulocyte colony-stimulating factor (G-CSF) was adopted for use in patients with septic shock due to melioidosis in December 1998. We compared the mortality rates from before and after the introduction of G-CSF therapy at the Royal Darwin Hospital (Darwin, Australia) during the period of 1989-2002. The mortality rate decreased from 95% to 10% after the introduction of G-CSF. Risk factors, the duration of illness before presentation, and the severity of illness were similar in both groups. A smaller decrease in mortality among patients in the intensive care unit who did not have melioidosis was observed, suggesting that other changes in management did not account for the magnitude of the benefit seen. We conclude that G-CSF may have contributed to the reduction in the mortality rate among patients with septic shock due to melioidosis.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10447
DOI: 10.1086/380456
Type: Journal Article
Subjects: Adolescent
Adult
Child
Female
Granulocyte Colony-Stimulating Factor
Humans
Intensive Care Units
Male
Melioidosis
Middle Aged
Shock, Septic
Thienamycins
Burkholderia pseudomallei
Appears in Collections:NT Health digital library

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.