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Title: Northern Territory perspectives on heart failure with comorbidities – understanding trial validity and exploring collaborative opportunities to broaden the evidence base.
Authors: Iyngkaran, P
Majoni, W
Cass, A
Sanders, Prashanthan
Ronco, C
Brady, S
Kangaharan, N
Ilton, M
Hare, D L
Thomas, M C
Affiliation: Royal Darwin Hospital, Flinders University, Darwin Private Hospital, Tiwi, NT 0811. Electronic address:
Royal Darwin Hospital, Department of Nephrology Division of Medicine. Electronic address:
Menzies School of Health Research, Casuarina NT 0811. Electronic address:
Centre for Heart Rhythm Disorders (CHRD), South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia. Electronic address:
Department of Nephrology Dialysis & Transplantation, International Renal Research Institute (IRRIV) San Bortolo Hospital, Vicenza, Italy. Electronic address:
Alice Springs Hospital, Alice Springs NT 0871. Electronic address:
Division of Medicine, Royal Darwin Hospital, Royal Darwin Hospital, Tiwi, NT 0810. Electronic address:
Royal Darwin Hospital, Royal Darwin Hospital, Tiwi, NT 0810. Electronic address:
Coordinator, Cardiovascular Research, University of Melbourne; Director of Heart Failure Services, Austin Health, Vic 3084. Electronic address:
Baker IDI Heart and Diabetes Institute, Central Melbourne Victoria 3004, Australia. Electronic address:
Issue Date: Jun-2015
Citation: Heart, lung & circulation 2015-06; 24(6): 536-43
Abstract: Congestive Heart Failure (CHF) is an ambulatory care sensitive condition, associated with significant morbidity and mortality, rarely with cure. Outpatient based pharmacological management represents the main and most important aspect of care, and is usually lifelong. This narrative styled opinion review looks at the pharmacological agents recommended in the guidelines in context of the Northern Territory (NT) of Australia. We explore the concept of validity, a term used to describe the basis of standardising a particular trial or study and the population to which it is applicable. We aim to highlight the problems of the current guidelines based approach. We also present alternatives that could utilise the core principles from major trials, while incorporating regional considerations, which could benefit clients living in the NT and remote Australia.
DOI: 10.1016/j.hlc.2014.12.007
Type: Journal Article
Subjects: Guidelines
Heart Failure
Indigenous Australians
Cardiovascular Agents
Clinical Trials as Topic
Evidence-Based Medicine
Health Services, Indigenous
Heart Failure
Northern Territory
Practice Guidelines as Topic
Remote Consultation
Reproducibility of Results
Outcome Assessment (Health Care)
Appears in Collections:NT Health digital library

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