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Title: Further evaluation of a rapid diagnostic test for melioidosis in an area of endemicity.
Authors: O'Brien, Mathew
Freeman, Kevin
Lum, Gary
Cheng, Allen C
Jacups, Susan P
Currie, Bart J
Affiliation: Menzies School of Health Research, Charles Darwin University, and Microbiology Laboratory, Pathology Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia..
Issue Date: May-2004
Citation: Journal of clinical microbiology 2004-05; 42(5): 2239-40
Abstract: Immunochromatographic test (ICT) kits for the rapid detection of immunoglobulin G (IgG) and IgM antibodies to Burkholderia pseudomallei were compared to the indirect hemagglutination (IHA) assay. In 138 culture-confirmed melioidosis cases, sensitivities were 80, 77, and 88% for IHA, ICT IgG, and ICT IgM, respectively. In a prospective study of 160 consecutive sera samples sent for melioidosis serology, respective specificities were 91, 90, and 69, positive predictive values were 41, 32, and 18, and negative predictive values were 99, 98, and 100%. ICT IgM kits are unreliable for diagnosis of melioidosis, but ICT IgG kits may be useful for diagnosing travelers presenting with possible melioidosis who return from regions where melioidosis is endemic.
ISSN: 0095-1137
Type: Comparative Study
Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't
Subjects: Antibodies, Bacterial
Burkholderia pseudomallei
Hemagglutination Tests
Immunoglobulin G
Immunoglobulin M
Northern Territory
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity
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