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Title: Cough, airway inflammation, and mild asthma exacerbation.
Authors: Chang, A B
Harrhy, V A
Simpson, J
Masters, I B
Gibson, P G
Affiliation: Flinders University NT Clinical School, Alice Springs Hospital, Northern Territory Department of Respiratory Medicine, Mater Children's Hospital Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW.
Issue Date: Apr-2002
Citation: Archives of disease in childhood 2002-04; 86(4): 270-5
Abstract: Prospective data on the temporal relation between cough, asthma symptoms, and airway inflammation in childhood asthma is unavailable. Using several clinical (diary, quality of life), lung function (FEV(1), FEV(1) variability, airway hyperresponsiveness), cough (diary, cough receptor sensitivity (CRS)), and inflammatory markers (sputum interleukin 8, eosinophilic cationic protein (ECP), myeloperoxidase; and serum ECP) of asthma severity, we prospectively described the course of these markers in children with asthma during a non-acute, acute, and resolution phase. A total of 21 children with asthma underwent these baseline tests; 11 were retested during days 1, 3, 7, and 28 of an exacerbation. Asthma exacerbations were characterised by increased asthma and cough symptoms and eosinophilic inflammation. Sputum ECP showed the largest increase and peaked later than clinical scores. Asthma scores consistently related to cough score only early in the exacerbation. Neither CRS nor cough scores related to any inflammatory marker. In mild asthma exacerbations, eosinophilic inflammation is dominant. In asthmatic children who cough as a dominant symptom, cough heralds the onset of an exacerbation and increased eosinophilic inflammation, but cough scores and CRS do not reflect eosinophilic airway inflammation.
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: Acute Disease
Child, Preschool
Forced Expiratory Volume
Prospective Studies
Pulmonary Eosinophilia
Quality of Life
Vital Capacity
Appears in Collections:NT Health digital library

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