Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10500
Title: Retinal Changes in Uncomplicated and Severe Plasmodium knowlesi Malaria.
Authors: Govindasamy, Gayathri
Barber, Bridget E
Ghani, Shuaibah A
William, Timothy
Grigg, Matthew J
Borooah, Shyamanga
Dhillon, Bal
Dondorp, Arjen M
Yeo, Tsin W
Anstey, Nicholas M
Maude, Richard J
Affiliation: Department of Ophthalmology, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia..
Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Northern Territory, Australia Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit..
Department of Ophthalmology, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia..
Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit Infectious Diseases Unit, Clinical Research Centre, Queen Elizabeth Hospital Jesselton Medical Centre, Kota Kinabalu, Sabah, Malaysia..
Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Northern Territory, Australia Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit..
College of Medicine and Veterinary Medicine, University of Edinburgh, United Kingdom..
College of Medicine and Veterinary Medicine, University of Edinburgh, United Kingdom..
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, United Kingdom..
Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Northern Territory, Australia Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore..
Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Northern Territory, Australia Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit Royal Darwin Hospital, Darwin, Northern Territory, Australia..
College of Medicine and Veterinary Medicine, University of Edinburgh, United Kingdom Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, United Kingdom..
Issue Date: 1-May-2016
Citation: The Journal of infectious diseases 2016-05-01; 213(9): 1476-82
Abstract: Plasmodium knowlesi causes severe malaria, but its pathogenesis is poorly understood. Retinal changes provide insights into falciparum malaria pathogenesis but have not been studied in knowlesi malaria. An observational study was conducted in Malaysian adults hospitalized with severe (n = 20) and nonsevere (n = 24) knowlesi malaria using indirect ophthalmoscopy (n = 44) and fundus photography (n = 29). The patients' median age was 44 years (range, 18-74 years). No coma or deaths occurred. Photography detected retinal changes in 11 of 12 patients (92%) with severe and 14 of 17 (82%) with nonsevere knowlesi malaria. Nonspecific retinal whitening occurred in 3 (35%) and 5 (29%) patients with severe and nonsevere disease, respectively; hemorrhages in 2 (17%) and 3 (18%); loss of retinal pigment epithelium in 1 (8%) and 4 (24%); and drusen in 9 (71%) and 12 (75%). All changes were mild, with no significant differences between severe and nonsevere disease. Patients with retinal hemorrhages had lower platelet counts than those without (median, 22 vs 43 × 10(9)/L; P= .04). The paucity of specific retinal findings associated with disease severity in knowlesi malaria contrasts with the retinopathy of severe adult falciparum malaria with and without coma, suggesting that falciparum-like microvascular sequestration in the brain is not a major component in severe knowlesi malaria pathogenesis.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10500
DOI: 10.1093/infdis/jiv746
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: malaria
plasmodium knowlesi
retinopathy
Adolescent
Adult
Aged
Female
Humans
Malaria
Malaysia
Male
Middle Aged
Retina
Retinal Vessels
Young Adult
Plasmodium knowlesi
Retinal Diseases
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