Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10510
Title: The multideterminant model of renal disease in a remote Australian Aboriginal population in the context of early life risk factors: lower birth weight, childhood post-streptococcal glomerulonephritis, and current body mass index influence levels of albuminuria in young Aboriginal adults.
Authors: Hoy, Wendy E
White, Andrew V
Tipiloura, Bernard
Singh, Gurmeet
Sharma, Suresh K
Bloomfield, Hilary
Swanson, Cheryl E
Dowling, Alison
McCredie, David A
Affiliation: Centre for Chronic Disease, University of Queensland, Currently James Cook University, Townsville, Queensland, Tiwi Community Elder and Project Officer, Nguiu, Bathurst Island, NT, Menzies School of Health Research, Charles Darwin University, and Royal Darwin Hospital, NT, and Royal Children's Hospital, Melbourne, University of Melbourne, Victoria, Australia..
Issue Date: 2015
Citation: Clinical nephrology 2015; 83(7 Suppl 1): 75-81
Abstract: Australian Aborigines in remote areas have very high rates of kidney disease, which is marked by albuminuria. We describe a "multihit" model of albuminuria in young adults in one remote Aboriginal community. Urinary albumin/creatinine ratios (ACR) were measured in all subjects who volunteered to participate in a community-wide health screen. Subjects for this study were young adults who had birth weights recorded and whose medical records were inspected for a history of post-streptococcal glomerulonephritis (PSGN). Urine ACR levels were evaluated in the context of birth weights, PSGN history and current BMI. 580 subjects (335 males and 245 females) who were aged 18 - 39 years at time of screening and qualified for inclusion. 26% of subjects had birth weights of < 2.5 kg, and the median birth weight was 2.8 kg. 23% of subjects had a remote history of PSGN, all 3 or more years earlier. Median BMI for the group was 21 kg/m2. Urine ACR levels exceeded the microalbuminuria threshold of 3.4 g/mol in 35.5% of subjects. Birth weight (inversely), remote PSGN, and current BMI were all independent predictors of ACR levels. Median levels of ACR were lowest in those with birth weights ≥ 2.5 kg, and no history of PSGN, intermediate in those with either birth weights < 2.5 kg or a history of PSGN, and highest in those with both low birth weights and a PSGN history. ACR levels were higher in those with BMIs above the median values, most notably in those with lower birth weights or a PSGN history or both. Much of the great excess of disease in this population is explained by high rates of the early life risk factors, low birth weight and PSGN. Their effects are expressed through amplification of ACR in the context of increasing age, and are further moderated by levels of current body size. Both early life risk factors are potentially modifiable.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10510
ISSN: 0301-0430
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: Adolescent
Adult
Albuminuria
Australia
Female
Glomerulonephritis
Humans
Incidence
Kidney Diseases
Male
Retrospective Studies
Risk Factors
Time Factors
Young Adult
Birth Weight
Body Mass Index
Oceanic Ancestry Group
Appears in Collections:NT Health digital library

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.