Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10557
Title: Establishing contemporary trends in hepatitis B sero-epidemiology in an Indigenous population.
Authors: Davies, Jane
Li, Shu Qin
Tong, Steven Y
Baird, Rob W
Beaman, Miles
Higgins, Geoff
Cowie, Benjamin C
Condon, John R
Davis, Joshua S
Affiliation: Department of Global and Tropical Health, Menzies School of Health Research, Darwin, Northern Territory, Australia.. The Infectious Diseases Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia..
Health Gains Planning Branch, Northern Territory Department of Health, Darwin, Northern Territory, Australia..
Department of Global and Tropical Health, Menzies School of Health Research, Darwin, Northern Territory, Australia.. Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.. Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, Victoria, Australia..
Territory Pathology, Royal Darwin Hospital, Darwin, Northern Territory, Australia..
Western Diagnostic Pathology, Myaree, Western Australia, Australia.. University of Western Australia, Perth, Western Australia, Australia.. University of Notre Dame Australia, Fremantle, Western Australia, Australia..
SA Pathology, Adelaide, South Australia, Australia..
Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, Victoria, Australia.. WHO Collaborating Centre for Viral Hepatitis, Doherty Institute, Melbourne, Victoria, Australia..
Department of Global and Tropical Health, Menzies School of Health Research, Darwin, Northern Territory, Australia.. Health Gains Planning Branch, Northern Territory Department of Health, Darwin, Northern Territory, Australia..
Department of Global and Tropical Health, Menzies School of Health Research, Darwin, Northern Territory, Australia.. John Hunter Hospital, New Lambton Heights, New South Wales, Australia..
Issue Date: 2017
Citation: PloS one 2017; 12(9): e0184082
Abstract: Indigenous populations globally are disproportionately affected by chronic hepatitis B virus (HBV) infection however contemporary sero-prevalence data are often absent. In the Indigenous population of the Northern Territory (NT) of Australia the unique C4 sub-genotype of HBV universally circulates. There are no studies of the sero-prevalence, nor the impact of the vaccination program (which has a serotype mismatch compared to C4), at a population-wide level. We examined all available HBV serology results obtained from the three main laboratories serving NT residents between 1991 and 2011. Data were linked with a NT government database to determine Indigenous status and the most recent test results for each individual were extracted as a cross-sectional database including 88,112 unique individuals. The primary aim was to obtain a contemporary estimate of HBsAg positivity for the NT by Indigenous status. Based on all tests from 2007-2011 (35,633 individuals), hepatitis B surface antigen (HBsAg) positivity was 3·40% (95%CI 3·19-3·61), being higher in Indigenous (6·08%[5·65%-6·53%]) than non-Indigenous (1·56%[1·38%-1·76%]) Australians, p<0·0001. Birth cohort analysis showed HBsAg positivity fell over time for Indigenous people, with this decrease commencing prior to universal infant vaccination (which commenced in 1990), with an ongoing but slower rate of decline since 1990, (0·23% decrease per year versus 0·17%). HBsAg positivity is high in the NT, particularly in the Indigenous population. HBsAg positivity has fallen over time but a substantial part of this decrease is due to factors other than the universal vaccination program.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10557
DOI: 10.1371/journal.pone.0184082
ORCID: http://orcid.org/0000-0002-3843-837X
Type: Journal Article
Subjects: Adult
Cross-Sectional Studies
Female
Hepatitis B
Hepatitis B Antibodies
Hepatitis B Surface Antigens
Hepatitis B virus
Humans
Immunization Programs
Male
Middle Aged
Northern Territory
Population Groups
Prevalence
Retrospective Studies
Seroepidemiologic Studies
Vaccination
Young Adult
Population Surveillance
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