Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10588
Title: An international, multicentre evaluation and description of Burkholderia pseudomallei infection in cystic fibrosis.
Authors: Geake, James B
Reid, David W
Currie, Bart J
Bell, Scott C
Bright-Thomas, Rowland
Dewar, Jane
Holden, Steve
Simmonds, Nicholas
Gyi, Khin
Kenna, Dervla
Waters, Valerie
Jackson, Mary
O'Sullivan, Brian
Taccetti, Giovanni
Kolbe, John
O'Carroll, Mark
Campbell, Dee
Jaksic, Mirjana
Radhakrishna, Naghmeh
Kidd, Timothy J
Flight, William
Affiliation: Department of Respiratory Medicine, The Lyell-McEwin Hospital, Haydown Road, Elizabeth Vale, 5112, South Australia, Australia. james.geake@health.sa.gov.au..
The Prince Charles Hospital, Rode Road, Chermside, Brisbane, 4032, Australia. david.reid@qimrberghofer.edu.au.. QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, 4006, Australia. david.reid@qimrberghofer.edu.au..
Menzies School of Health Research and Royal Darwin Hospital, Darwin, NT, Australia. bart.currie@menzies.edu.au..
The Prince Charles Hospital, Rode Road, Chermside, Brisbane, 4032, Australia. scott.bell@qld.health.gov.au.. QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, 4006, Australia. scott.bell@qld.health.gov.au..
Issue Date: 9-Oct-2015
Citation: BMC pulmonary medicine 2015-10-09; 15: 116
Abstract: Several cases of Burkholderia pseudomallei infection in CF have been previously reported. We aimed to identify all cases globally, risk factors for acquisition, clinical consequences, and optimal treatment strategies. We performed a literature search to identify all published cases of B. pseudomallei infection in CF. In addition we hand-searched respiratory journals, and contacted experts in infectious diseases and CF around the world. Supervising clinicians for identified cases were contacted and contemporaneous clinical data was requested. 25 culture-confirmed cases were identified. The median age at acquisition was 21 years, mean FEV1 % predicted was 60 %, and mean BMI was 19.5 kg/m(2). The location of acquisition was northern Australia or south-east Asia for most. 19 patients (76 %) developed chronic infection, which was usually associated with clinical decline. Successful eradication strategies included a minimum of two weeks of intravenous ceftazidime, followed by a consolidation phase with trimethoprim/sulfamethoxazole, and this resulted in a higher chance of success when instituted early. Three cases of lung transplantation have been recorded in the setting of chronic B. pseudomallei infection. Chronic carriage of B. pseudomallei in patients with CF appears common after infection, in contrast to the non-CF population. This is often associated with an accelerated clinical decline. Lung transplantation has been performed in select cases of chronic B. pseudomallei infection.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10588
DOI: 10.1186/s12890-015-0109-9
Type: Journal Article
Subjects: Adolescent
Adult
Anti-Bacterial Agents
Australasia
Ceftazidime
Child
Cystic Fibrosis
Europe
Female
Forced Expiratory Volume
Humans
Male
Melioidosis
North America
Retrospective Studies
Young Adult
Burkholderia pseudomallei
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