Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10596
Title: The Epidemiology of Staphylococcus aureus and Panton-Valentine Leucocidin (pvl) in Central Australia, 2006-2010.
Authors: Hewagama, S
Spelman, T
Woolley, M
McLeod, J
Gordon, D
Einsiedel, L
Affiliation: Alice Springs Hospital, Alice Springs, NT, Australia. sals7au@yahoo.com.au..
Flinders University/Northern Territory Rural Clinical School, Alice Springs, NT, Australia..
SA Pathology, Adelaide, Australia..
Alice Springs Hospital, Alice Springs, NT, Australia.. NT Pathology, Alice Springs, NT, Australia..
SA Pathology, Adelaide, Australia..
Alice Springs Hospital, Alice Springs, NT, Australia.. Flinders University/Northern Territory Rural Clinical School, Alice Springs, NT, Australia.. Baker IDI Heart and Diabetes Institute, Alice Springs, NT, Australia..
Issue Date: 8-Aug-2016
Citation: BMC infectious diseases 2016-08-08; 16: 382
Abstract: The Central Australian Indigenous population has a high incidence of Staphylococcus aureus bacteremia (SAB) but little is known about the local molecular epidemiology. Prospective observational study of bacteremic and nasal colonizing S.aureus isolates between June 2006 to June 2010. All isolates underwent single nucleotide polymorphism (SNP) genotyping and testing for the presence of the Panton-Valentine Leucocidin (pvl) gene. Invasive isolates (n = 97) were predominantly ST93 (26.6 %) and pvl positive (54.3 %), which was associated with skin and soft tissue infections (OR 4.35, 95 % CI 1.16, 16.31). Non-multiresistant MRSA accounted for 31.9 % of bacteremic samples and showed a trend to being healthcare associated (OR 2.16, 95 % CI 0.86, 5.40). Non-invasive isolates (n = 54) were rarely ST93 (1.9 %) or pvl positive (7.4 %). In Central Australia, ST93 was the dominant S.aureus clone, and was frequently pvl positive and associated with an aggressive clinical phenotype. Whether non-nasal carriage is more important with invasive clones or whether colonization occurs only transiently remains to be elucidated.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10596
DOI: 10.1186/s12879-016-1698-5
ORCID: http://orcid.org/0000-0003-4329-3571
Type: Journal Article
Observational Study
Subjects: Panton-Valentine Leucocidin
ST93
Staphylococcus aureus
Adolescent
Adult
Aged
Aged, 80 and over
Australia
Bacteremia
Bacterial Toxins
Carrier State
Child
Child, Preschool
Exotoxins
Female
Genotype
Humans
Infant
Leukocidins
Male
Methicillin-Resistant Staphylococcus aureus
Middle Aged
Molecular Epidemiology
Nasopharynx
Polymorphism, Single Nucleotide
Prospective Studies
Soft Tissue Infections
Staphylococcal Infections
Staphylococcal Skin Infections
Staphylococcus aureus
Young Adult
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