Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10632
Title: The new screening program to prevent cervical cancer using HPV DNA: getting the balance right in maintaining quality.
Authors: Garland, Suzanne M
Dimech, Wayne
Collignon, Peter
Cooley, Louise
Nimmo, Graeme R
Smith, David W
Baird, Rob
Rawlinson, William
Costa, Anna-Maria
Higgins, Geoff
Affiliation: Department of Microbiology and Infectious Diseases, Royal Women's Hospital, Parkville, Australia.. Infection and Immunity Murdoch Children's Research Institute, Parkville, Australia.. Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Australia..
National Serology Reference Laboratory, Australia (NRL), Fitzroy, Australia..
Infectious Diseases and Microbiology, Canberra Hospital, Garran, Australia.. Medical School, Australian National University, Australia..
Department of Microbiology and Infectious Diseases, Royal Hobart Hospital, Hobart, Australia.. Department of Microbiology, Pathology Queensland Central Laboratory, Herston, Australia.. Department of Microbiology, Griffith University School of Medicine, Southport, Australia.. Department of Microbiology, PathWest Laboratory Medicine WA, Nedlands, Australia.. Faculty of Health and Medical Sciences, University of Western Australia, Nedlands, Australia.. Territory Pathology, Infectious Diseases, Royal Darwin Hospital, Department of Health and Families, Tiwi, Australia.. Virology, Serology and OTDS Laboratories, NSW Health Pathology, Randwick, Australia.. Department of Microbiology, The Royal Children's Hospital, Parkville, Australia.. Microbiology and Infectious Disease, South Australia Pathology, North Terrace, Australia..
Department of Microbiology and Infectious Diseases, Royal Hobart Hospital, Hobart, Australia..
Department of Microbiology, Pathology Queensland Central Laboratory, Herston, Australia.. Department of Microbiology, Griffith University School of Medicine, Southport, Australia..
Department of Microbiology, PathWest Laboratory Medicine WA, Nedlands, Australia.. Faculty of Health and Medical Sciences, University of Western Australia, Nedlands, Australia..
Territory Pathology, Infectious Diseases, Royal Darwin Hospital, Department of Health and Families, Tiwi, Australia..
Virology, Serology and OTDS Laboratories, NSW Health Pathology, Randwick, Australia..
Department of Microbiology and Infectious Diseases, Royal Women's Hospital, Parkville, Australia.. Department of Microbiology, The Royal Children's Hospital, Parkville, Australia..
Microbiology and Infectious Disease, South Australia Pathology, North Terrace, Australia..
Issue Date: Oct-2018
Citation: The journal of pathology. Clinical research 2018-10; 4(4): 207-212
Abstract: Along with the reduction in human papillomavirus (HPV) infection and cervical abnormalities as a result of the successful HPV vaccination program, Australia is adopting a new screening strategy. This involves a new paradigm moving from cervical cytological screening to molecular nucleic acid technology (NAT), using HPV DNA assays as primary screening methodology for cervical cancer prevention. These assays must strike a balance between sufficient clinical sensitivity to detect or predict high-grade cervical intraepithelial lesions, the precursor to cervical cancer, without being too sensitive and detecting transient infection not destined for disease. Ensuring the highest quality HPV NAT is thus a priority in order to reduce the possibility of falsely negative screens and manage the risk associated with false positive HPV NAT test results. How to do this needs informed discussion and on-going refinement of the screening algorithm. This is of relevance as more countries move to more sensitive HPV NAT tests for secondary prevention of cervical cancer and as more HPV assays become available.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10632
DOI: 10.1002/cjp2.110
ORCID: http://orcid.org/0000-0002-6869-311X
Type: Journal Article
Subjects: HPV
nucleic acid technology
quality assurance
quality control
Appears in Collections:NT Health digital library

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.