Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10670
Title: Gastrointestinal amyloidosis in Australian indigenous patients.
Authors: Frommer, D J
Fernandes, D
Pawar, G
Goud, R
Affiliation: Department of Medicine, Alice Springs Hospital, Alice Springs, Northern Territory, Australia..
Issue Date: Jun-2014
Citation: Internal medicine journal 2014-06; 44(6): 605-9
Abstract: This study documents the symptoms, racial distribution, pathological findings and outcomes of patients diagnosed with gastrointestinal amyloidosis in Alice Springs Hospital. In a 4 year retrospective survey. 9 patients, all indigenous, 7F/2M, had biopsy proven gastrointestinal amyloidosis. Four out of four patients tested were found to have AA amyloidosis. Presenting symptoms included diarrhoea, bloody in some, vomiting and abdominal pain. All but one had diabetes mellitus, type 2. Multiple infections were common and most patients had low serum albumin and transferrin concentrations but high serum ferritin concentrations. Five of the patients died, and the gastrointestinal symptoms of the remaining 4 remitted. Gastrointestinal amyloidosis should be included in the differential diagnosis of indigenous patients presenting with chronic diarrhoea, vomiting or abdominal pain. It carries a grave prognosis, is probably secondary to chronic infections but is potentially reversible.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10670
DOI: 10.1111/imj.12450
Type: Journal Article
Subjects: amyloidosis
indigenous
pathology
prognosis
symptom
Abdominal Pain
Adult
Aged
Aged, 80 and over
Amyloidosis
Bacterial Infections
C-Reactive Protein
Candidiasis
Cardiovascular Diseases
Comorbidity
Deltaretrovirus Infections
Diabetes Mellitus, Type 2
Diarrhea
Dyslipidemias
Female
Ferritins
Gastrointestinal Diseases
Gastrointestinal Hemorrhage
Humans
Hypoalbuminemia
Male
Middle Aged
Northern Territory
Prognosis
Renal Insufficiency, Chronic
Serum Amyloid A Protein
Transferrin
Vomiting
Oceanic Ancestry Group
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