Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10688
Title: Retinal perfusion changes in radiation retinopathy.
Authors: Rose, Kalpana
Krema, Hatem
Durairaj, Priya
Dangboon, Wantanee
Chavez, Yael
Kulasekara, Susith I
Hudson, Christopher
Affiliation: School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada.. Department of Ophthalmology and Vision Sciences, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada..
Department of Ophthalmology and Vision Sciences, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.. Ocular Oncology Service, Princess Margaret Cancer Centre/University Health Network, Toronto, Ontario, Canada..
Ocular Oncology Service, Princess Margaret Cancer Centre/University Health Network, Toronto, Ontario, Canada..
Ocular Oncology Service, Princess Margaret Cancer Centre/University Health Network, Toronto, Ontario, Canada..
Ocular Oncology Service, Princess Margaret Cancer Centre/University Health Network, Toronto, Ontario, Canada..
Department of Ophthalmology, Royal Darwin Hospital, Darwin, Northern Territory, Australia..
School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada.. Department of Ophthalmology and Vision Sciences, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada..
Issue Date: Sep-2018
Citation: Acta ophthalmologica 2018-09; 96(6): e727-e731
Abstract: To investigate retinal blood flow and oxygen saturation changes in patients diagnosed with retinopathy following plaque radiation treatment to treat choroidal melanoma. Eight patients (mean age 55.75 years, SD 12.58 years) who have developed unilateral ischaemic radiation-related retinopathy as confirmed by wide-field fluorescein angiography were recruited for the study. The fellow eye with no other ocular or retinal pathology was used as control. Both eyes underwent measurement of total retinal blood flow (TRBF) and retinal blood oxygen saturation using prototype methodologies of Doppler Spectral Domain Optical Coherence Tomography (OCT) and Hyperspectral Retinal Camera, respectively. The average TRBF in the retinopathy eye was significantly lower compared to the fellow eye (33.48 ± 12.73 μl/min versus 50.37 ± 15.26 μl/min; p = 0.013). The arteriolar oxygen saturation (SaO2 ) and venular oxygen saturation (SvO2 ) were higher in the retinopathy eye compared to the fellow eye (101.11 ± 4.26%, versus 94.45 ± 5.79%; p = 0.008) and (62.96 ± 11.05% versus 51.24 ± 6.88%, p = 0.051), respectively. The ionizing radiation seems to have an impact on the TRBF, SaO2 and SvO2 , clinically presenting similar to a rapidly developing diabetic retinopathy. The results show an altered retinal vascular physiology in patients with radiation-related retinopathy.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10688
DOI: 10.1111/aos.13797
ORCID: http://orcid.org/0000-0001-8484-6457
Type: Journal Article
Subjects: brachytherapy
choroidal melanoma
oxygen saturation
radiation retinopathy
retinal blood flow
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