Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10718
Title: Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria.
Authors: Salwati, Ervi
Minigo, Gabriela
Woodberry, Tonia
Piera, Kim A
de Silva, Harini D
Kenangalem, Enny
Tjitra, Emiliana
Coppel, Ross L
Price, Ric N
Anstey, Nicholas M
Plebanski, Magdalena
Affiliation: National Institute of Health Research and Development (NIHRD), Ministry of Health, Jakarta, Indonesia..
Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.. Department of Immunology, Monash University, Victoria, Australia..
Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia..
Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia..
Department of Microbiology, Monash University, Victoria, Australia..
Menzies-NIHRD Collaborative Research Program and District Health Authority, Timika, Papua, Indonesia..
National Institute of Health Research and Development (NIHRD), Ministry of Health, Jakarta, Indonesia..
Department of Microbiology, Monash University, Victoria, Australia..
Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.. Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford.. Division of Medicine, Royal Darwin Hospital, Darwin, Australia..
Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.. Division of Medicine, Royal Darwin Hospital, Darwin, Australia..
Department of Immunology, Monash University, Victoria, Australia..
Issue Date: 15-Apr-2011
Citation: The Journal of infectious diseases 2011-04-15; 203(8): 1192-1199
Abstract: Plasmodium falciparum and Plasmodium vivax are co-endemic in the Asia-Pacific region. Their capacity to induce and sustain diverse T-cell responses underpins protective immunity. We compared T-cell responses to the largely conserved merozoite surface protein-5 (PfMSP5) during acute and convalescent falciparum and vivax malaria. Lymphoproliferation and IFN--γ secretion to PfMSP5 and purified protein derivate were quantified in adults with falciparum (n=34), and vivax malaria (n=12) or asymptomatic residents (n=10) of Papua, Indonesia. Responses were reassessed 7-28 days following treatment. The frequency of IFN-γ responders to PfMSP5 was similar in acute falciparum (63%) or vivax (67%) malaria. However, significantly more IFN-γ-secreting cells were detectable during vivax compared with falciparum infection. Purified protein derivative responses showed a similarly enhanced pattern. While rapidly lost in vivax patients, PfMSP5-specific responses in falciparum malaria remained to day 28. By contrast, frequency and magnitude of lymphoproliferation to PfMSP5 were similar for falciparum and vivax infections. Cellular PfMSP5-specific responses are most frequent during either acute falciparum or vivax malaria, indicating functional T-cell responses to conserved antigens. Both effector and central memory T-cell functions are increased. Greater IFN-γ responses in acute P. vivax, suggest enhancement of pre-existing effector T-cells during acute vivax infection.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10718
DOI: 10.1093/infdis/jiq166
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: Adult
Antigens, Protozoan
Female
Humans
Immunity, Cellular
Malaria, Falciparum
Malaria, Vivax
Male
Membrane Proteins
Papua New Guinea
Plasmodium falciparum
Plasmodium vivax
Species Specificity
Appears in Collections:NT Health digital library

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.