Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10738
Title: Variable virulence factors in Burkholderia pseudomallei (melioidosis) associated with human disease.
Authors: Sarovich, Derek S
Price, Erin P
Webb, Jessica R
Ward, Linda M
Voutsinos, Marcos Y
Tuanyok, Apichai
Mayo, Mark
Kaestli, Mirjam
Currie, Bart J
Affiliation: Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia..
Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia..
Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia..
Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia..
Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia..
Department of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawai'i, Honolulu, Hawai'i, United States of America..
Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia..
Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia..
Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; Infectious Diseases Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia..
Issue Date: 2014
Citation: PloS one 2014; 9(3): e91682
Abstract: Burkholderia pseudomallei is a Gram-negative environmental bacterium that causes melioidosis, a potentially life-threatening infectious disease affecting mammals, including humans. Melioidosis symptoms are both protean and diverse, ranging from mild, localized skin infections to more severe and often fatal presentations including pneumonia, septic shock with multiple internal abscesses and occasionally neurological involvement. Several ubiquitous virulence determinants in B. pseudomallei have already been discovered. However, the molecular basis for differential pathogenesis has, until now, remained elusive. Using clinical data from 556 Australian melioidosis cases spanning more than 20 years, we identified a Burkholderia mallei-like actin polymerization bimA(Bm) gene that is strongly associated with neurological disease. We also report that a filamentous hemagglutinin gene, fhaB3, is associated with positive blood cultures but is negatively correlated with localized skin lesions without sepsis. We show, for the first time, that variably present virulence factors play an important role in the pathogenesis of melioidosis. Collectively, our study provides a framework for assessing other non-ubiquitous bacterial virulence factors and their association with disease, such as candidate loci identified from large-scale microbial genome-wide association studies.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10738
DOI: 10.1371/journal.pone.0091682
Type: Journal Article
Subjects: Australia
Burkholderia pseudomallei
Humans
Melioidosis
Microfilament Proteins
Virulence
Virulence Factors
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