Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10783
Title: Hepatitis B virus and human T-cell lymphotropic virus type 1 co-infection in the Northern Territory, Australia.
Authors: Marr, Ian
Davies, Jane
Baird, Rob W
Affiliation: Infectious Diseases Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Territory Pathology, Royal Darwin Hospital, Darwin, Northern Territory, Australia. Electronic address: Ian_Marr@gmx.com..
Infectious Diseases Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Menzies School of Health Research, Darwin, Northern Territory, Australia..
Territory Pathology, Royal Darwin Hospital, Darwin, Northern Territory, Australia..
Issue Date: May-2017
Citation: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2017-05; 58: 90-95
Abstract: To establish the relationship between hepatitis B virus (HBV) and human T-cell lymphotropic virus type 1 (HTLV-1) serological markers in the Northern Territory, Australia. A retrospective serological study of patients presenting to public healthcare facilities in the Northern Territory between 2008 and 2015 was performed in order to determine the presence and relationships of serological markers of HBV and HTLV-1. Seven hundred and forty individual patients were found to be serologically positive for HTLV-1 in the Northern Territory over the 8-year period. Hepatitis B results were available for 521 of these patients. Hepatitis B surface antigen (HBsAg) positivity was demonstrated in 15.9% (83/521) of this cohort, which was significantly different to the HTLV-1-negative group (3.7%, 125/3354) (p<0.001). Excluding individuals with isolated hepatitis B surface antibody (anti-HBs), those in the HTLV-1-positive group had a higher HBV exposure history (67.5%, 352/521) when compared to HTLV-1-negative individuals (37.8%, 1259/3354) (p<0.001). HTLV-1-positive individuals had a lower prevalence of HBV combined anti-HBs and hepatitis B core antibody (anti-HBc) positive markers compared to those who were HTLV-1-negative (56.3% (198/352) versus 73.8% (937/1269), respectively; p<0.001). A significantly higher prevalence rate of HBV was found in HTLV-1-positive individuals from the Northern Territory. When considering the higher exposure to HBV in HTLV-1-positive individuals, the clearance of HBV appears lower than in those individuals testing HTLV-1-negative. A lower prevalence of clearance in HTVL-1-positive individuals than in HTLV-1-negative individuals, as signified by formation of HBVcAb and HBVsAb in HTVL-1 positive individual's may equate to higher prevalence of ongoing coinfection.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10783
DOI: 10.1016/j.ijid.2017.03.010
Type: Journal Article
Subjects: Australia
Co-infection
HTLV-1
Hepatitis B virus
Northern Territory
Adult
Aged
Biomarkers
Coinfection
DNA, Viral
Female
HTLV-I Infections
Hepatitis B
Hepatitis B Antibodies
Hepatitis B Surface Antigens
Hepatitis B virus
Human T-lymphotropic virus 1
Humans
Male
Middle Aged
Northern Territory
Prevalence
Retrospective Studies
Serologic Tests
Appears in Collections:NT Health digital library

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