Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10787
Title: Pharmacokinetics of Piperacillin in Critically Ill Australian Indigenous Patients with Severe Sepsis.
Authors: Tsai, Danny
Stewart, Penelope
Goud, Rajendra
Gourley, Stephen
Hewagama, Saliya
Krishnaswamy, Sushena
Wallis, Steven C
Lipman, Jeffrey
Roberts, Jason A
Affiliation: Burns, Trauma and Critical Care Research Centre, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia d.tsai@uq.edu.au.. Department of Intensive Care Medicine, Alice Springs Hospital, Alice Springs, Northern Territory, Australia.. Pharmacy Department, Alice Springs Hospital, Alice Springs, Northern Territory, Australia..
Department of Intensive Care Medicine, Alice Springs Hospital, Alice Springs, Northern Territory, Australia..
Department of Intensive Care Medicine, Alice Springs Hospital, Alice Springs, Northern Territory, Australia..
Emergency Department, Alice Springs Hospital, Alice Springs, Northern Territory, Australia..
Department of Medicine, Alice Springs Hospital, Alice Springs, Northern Territory, Australia.. Department of Infectious Diseases, The Northern Hospital, Epping, Melbourne, Victoria, Australia..
Department of Medicine, Alice Springs Hospital, Alice Springs, Northern Territory, Australia.. Monash Infectious Diseases, Monash Health, Clayton, Melbourne, Victoria, Australia..
Burns, Trauma and Critical Care Research Centre, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia..
Burns, Trauma and Critical Care Research Centre, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia.. Department of Intensive Care Medicine, The Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia..
Burns, Trauma and Critical Care Research Centre, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia.. Department of Intensive Care Medicine, The Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.. School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia..
Issue Date: 2016
Citation: Antimicrobial agents and chemotherapy 2016; 60(12): 7402-7406
Abstract: There are no available pharmacokinetic data to guide piperacillin dosing in critically ill Australian Indigenous patients despite numerous reported physiological differences. This study aimed to describe the population pharmacokinetics of piperacillin in critically ill Australian Indigenous patients with severe sepsis. A population pharmacokinetic study of Indigenous patients with severe sepsis was conducted in a remote hospital intensive care unit. Plasma samples were collected over two dosing intervals and assayed by validated chromatography. Population pharmacokinetic modeling was conducted using Pmetrics. Nine patients were recruited, and a two-compartment model adequately described the data. The piperacillin clearance (CL), volume of distribution of the central compartment (Vc), and distribution rate constants from the central to the peripheral compartment and from the peripheral to the central compartment were 5.6 ± 3.2 liters/h, 14.5 ± 6.6 liters, 1.5 ± 0.4 h-1, and 1.8 ± 0.9 h-1, respectively, where CL and Vc were found to be described by creatinine clearance (CLCR) and total body weight, respectively. In this patient population, piperacillin demonstrated high interindividual pharmacokinetic variability. CLCR was found to be the most important determinant of piperacillin pharmacokinetics.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10787
DOI: 10.1128/AAC.01657-16
ORCID: 0000-0002-7059-8808
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: APACHE
Adult
Anti-Bacterial Agents
Body Weight
Creatinine
Critical Illness
Female
Humans
Intensive Care Units
Male
Microbial Sensitivity Tests
Middle Aged
Piperacillin
Sepsis
Oceanic Ancestry Group
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