Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10830
Title: Associations of mortality and cardiovascular disease risks with diabetes and albuminuria in urban Indigenous Australians: the DRUID follow-up study.
Authors: Barr, E L M
Cunningham, J
Tatipata, S
Dunbar, T
Kangaharan, N
Guthridge, S
Li, S Q
Condon, J R
Shaw, J E
O'Dea, K
Maple-Brown, L J
Affiliation: Menzies School of Health Research, Darwin, Australia.. Baker Heart and Diabetes Institute, Melbourne, Australia..
Menzies School of Health Research, Darwin, Australia..
Menzies School of Health Research, Darwin, Australia..
Charles Darwin University, Darwin, Australia..
Royal Darwin Hospital, Darwin, Australia..
Menzies School of Health Research, Darwin, Australia.. Health Gains Planning, Northern Territory Department of Health, Darwin, Australia..
Health Gains Planning, Northern Territory Department of Health, Darwin, Australia..
Menzies School of Health Research, Darwin, Australia..
Baker Heart and Diabetes Institute, Melbourne, Australia..
University of South Australia, Adelaide, Australia.. University of Melbourne, Melbourne, Australia..
Menzies School of Health Research, Darwin, Australia.. Royal Darwin Hospital, Darwin, Australia..
Issue Date: Jul-2017
Citation: Diabetic medicine : a journal of the British Diabetic Association 2017-07; 34(7): 946-957
Abstract: To assess the relationships of diabetes and albuminuria with all-cause mortality and cardiovascular disease outcomes in a population without prior cardiovascular disease using data from the Darwin Region Urban Indigenous Diabetes (DRUID) study. We conducted a prospective cohort study of 706 participants (aged 15-81 years, 68% women) without prior cardiovascular disease who underwent a 75-g oral glucose tolerance test. Deaths and fatal or non-fatal cardiovascular disease were determined over 7 years, and hazard ratios with 95% CIs and population attributable risks were estimated for baseline glycaemia and albuminuria. Compared with normoglycaemia and after adjustment for age, sex, hypertension, dyslipidaemia and smoking, known diabetes was associated with an adjusted hazard ratio of 4.8 (95% CI 1.5-14.7) for all-cause mortality and 5.6 (95% CI 2.1-15.2) for cardiovascular disease. Compared with normoalbuminuria, the respective adjusted risks for macroalbuminuria were 10.9 (95% CI 3.7-32.1) and 3.9 (95% CI 1.4-10.8). The Adjusted all-cause mortality and cardiovascular disease estimated population attributable risks for diabetes were 27% and 32%, and for albuminuria they were 32% and 21%, respectively. In our study population, the burden of mortality and cardiovascular disease was largely driven by diabetes and albuminuria. This finding on the influence of diabetes and albuminuria is consistent with reports in other high-risk Indigenous populations and should be better reflected in risk scores and intervention programmes.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10830
DOI: 10.1111/dme.13360
ORCID: http://orcid.org/0000-0003-4284-1716
Type: Journal Article
Observational Study
Subjects: Adolescent
Adult
Aged
Albuminuria
Australia
Cardiovascular Diseases
Cohort Studies
Diabetic Angiopathies
Diabetic Cardiomyopathies
Diabetic Nephropathies
Female
Follow-Up Studies
Health Surveys
Humans
Incidence
Male
Mortality
Oceanic Ancestry Group
Prevalence
Proportional Hazards Models
Prospective Studies
Renal Insufficiency, Chronic
Risk Factors
Urban Health
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