Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10900
Title: Nocardiosis in the Tropical Northern Territory of Australia, 1997-2014.
Authors: McGuinness, Sarah L
Whiting, Sarah E
Baird, Rob
Currie, Bart J
Ralph, Anna P
Anstey, Nicholas M
Price, Ric N
Davis, Joshua S
Tong, Steven Y C
Affiliation: Department of Infectious Diseases and..
Department of Infectious Diseases and..
Department of Infectious Diseases and; Territory Pathology, Royal Darwin Hospital, Darwin, Australia..
Department of Infectious Diseases and; Global and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, Australia..
Department of Infectious Diseases and; Global and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, Australia..
Department of Infectious Diseases and; Global and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, Australia..
Department of Infectious Diseases and; Global and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, Australia;; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom..
Global and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, Australia;; Department of Infectious Diseases, John Hunter Hospital, Newcastle, Australia..
Department of Infectious Diseases and; Global and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, Australia..
Issue Date: Oct-2016
Citation: Open forum infectious diseases 2016-10; 3(4): ofw208
Abstract: Nocardia is an opportunistic pathogen that can cause life-threatening disease. We aimed to characterize the epidemiological, microbiological, and clinical features of nocardiosis in the tropical north of Australia. We conducted a retrospective cohort study of nocardiosis diagnosed between 1997 and 2014. Population-based incidences were calculated using district population data. Clinically significant nocardiosis was identified in 61 patients. The unadjusted population-based annual incidence of nocardiosis was 2.02 (95% confidence interval [CI], 1.55-2.60) per 100000 people and was 1.7 (95% CI, .96-2.90) fold higher in Indigenous compared with non-Indigenous persons (P = .027). Of 61 patients, 47 (77%) had chronic lung disease, diabetes, and/or hazardous alcohol consumption; 22 (36%) were immunocompromised; and 8 (13%) had no identified comorbidities. Disease presentations included pulmonary (69%; 42 of 61), cutaneous (13%; 8 of 61), and disseminated nocardiosis (15%; 9 of 61). The most commonly identified species were Nocardia asteroides and Nocardia cyriacigeorgica (each 11%). Linezolid was the only antimicrobial to which isolates were universally susceptible; 89% (48 of 54), 60% (32 of 53), and 48% (26 of 54) of isolates were susceptible to trimethoprim-sulfamethoxazole, ceftriaxone, and imipenem, respectively. Eighteen patients (30%) required intensive care unit (ICU) admission, and 1-year mortality was 31%. The incidence of nocardiosis in tropical Australia is amongst the highest reported globally. Nocardiosis occurs in both immunocompromised and immunocompetent hosts, and it is associated with high rates of ICU admission, 1-year mortality, and resistance to commonly recommended antimicrobials. Diagnosis should be considered in patients with consistent clinical features, particularly if they are Indigenous or have chronic lung disease.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10900
DOI: 10.1093/ofid/ofw208
ISSN: 2328-8957
Type: Journal Article
Subjects: Nocardia
epidemiology
immunocompromised host
nocardiosis
treatment.
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