Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10902
Title: Cross-sectional associations of albuminuria among Aboriginal and Torres Strait Islander adults: the eGFR Study.
Authors: Hughes, J T
Maple-Brown, L J
Thomas, M
Lawton, P D
Sinha, A
Cass, A
Barzi, F
Jones, Grd
Jerums, G
MacIsaac, R J
O'Dea, K
Hoy, W E
Affiliation: Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.. Department of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia..
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.. Department of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia..
Royal Perth Hospital, Perth, Australia..
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia..
Cairns Base Hospital and Diabetes Centre, Cairns, Australia..
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia..
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia..
SydPath, St Vincent's Hospital, Sydney, Australia..
University of Melbourne, Melbourne.. Austin Health, Melbourne, Australia..
University of Melbourne, Melbourne.. Department of Endocrinology and Diabetes, St Vincent's Hospital, Melbourne..
Centre for Population Health Research, Australia..
Centre for Chronic Disease, The University of Queensland, Australia..
Issue Date: Jan-2018
Citation: Nephrology (Carlton, Vic.) 2018-01; 23(1): 37-45
Abstract: To describe the detailed associations of albuminuria among a contemporary cohort of Aboriginal and Torres Strait Islander people to inform strategies for chronic kidney disease prevention and management. A cross-sectional analysis of Indigenous participants of the eGFR Study. Clinical, biochemical and anthropometric measures were collected (including body-circumferences, blood pressure (BP); triglycerides, HbA1c, liver function tests, creatinine; urine- microscopic-haem, albumin: creatinine ratio (ACR), prescriptions- angiotensin converting enzyme inhibitor or angiotensin receptor II antagonist (ACEI/ARB). Albuminuria and diabetes were defined by an ACR>3.0 mg/mmol, and HbA1c≥48 mmol/mol or prior history respectively. Waist: hip ratio (WHR), and estimated glomerular filtration rate (eGFR) were calculated. ACR was non-normally distributed; a logarithmic transformation was applied (in base 2), with each unit increase in log2-albuminuria representing a doubling of ACR. 591 participants were assessed (71% Aboriginal, 61.6% female, mean age 45.1 years, BMI 30.2 kg/m2 , WHR 0.94, eGFR 99.2 ml/min/1.73m2 ). The overall prevalence of albuminuria, diabetes, microscopic-haem and ACEI/ARB use was 41.5%, 41.5%, 17.8% and 34.7% respectively; 69.3% of adults with albuminuria and diabetes received an ACEI/ARB. Using multivariable linear regression modelling, the potentially modifiable factors independently associated with log2-albuminuria were microscopic-haem, diabetes, WHR, systolic BP, alkaline phosphatase (all positive) and eGFR (inverse). Albuminuria is associated with diabetes, central obesity and haematuria. High ACEI/ARB prescribing for adults with diabetes and albuminuria was observed. Further understanding of the links between fat deposition, haematuria and albuminuria is required.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10902
DOI: 10.1111/nep.12956
ORCID: http://orcid.org/0000-0002-1867-4156
Type: Journal Article
Appears in Collections:NT Health digital library

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.