Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10919
Title: Geographic consistency in dominant, non-typeable Haemophilus influenzae genotypes colonising four distinct Australian paediatric groups: a cohort study.
Authors: Smith-Vaughan, Heidi C
Beissbarth, Jemima
Bowman, Jacinta
Hare, Kim M
Price, Erin P
Pickering, Janessa
Lehmann, Deborah
Chang, Anne B
Morris, Peter S
Marsh, Robyn L
Leach, Amanda J
Affiliation: Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory Australia.. School of Medicine, Griffith University, Gold Coast, Queensland Australia..
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory Australia..
Department of Microbiology and Infectious Diseases, PathWest Laboratory Medicine, Perth, Western Australia Australia..
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory Australia..
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory Australia..
Telethon Kids Institute, The University of Western Australia, Perth, Western Australia Australia.. School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia Australia..
Telethon Kids Institute, The University of Western Australia, Perth, Western Australia Australia..
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory Australia.. Department of Respiratory and Sleep Medicine, Queensland Children's Medical Research Institute, Children's Health, Queensland University of Technology, Brisbane, Queensland Australia..
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory Australia.. Royal Darwin Hospital, Darwin, Northern Territory Australia..
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory Australia..
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory Australia..
Issue Date: 2016
Citation: Pneumonia (Nathan Qld.) 2016; 8: 13
Abstract: Non-typeable Haemophilus influenzae (NTHi)-associated ear and respiratory diseases (including pneumonia) represent a major health burden in many parts of the world. NTHi strains retrieved from the upper airways commonly reflect those found in the lower airways. Despite growing genomic and genotyping data on NTHi, there remains a limited understanding of global and regional NTHi population structures. The aim of this study was to determine whether nasopharyngeal carriage in four Australian paediatric groups at varying risk of NTHi colonisation was dominated by the same NTHi genotypes. Genotyping data generated by PCR-ribotyping were evaluated for 3070 NTHi isolates colonising the nasopharynges of Aboriginal and non-Aboriginal children enrolled in four longitudinal studies in three separate urban and remote regions of Australia. Several NTHi PCR-ribotypes dominated in nasopharyngeal carriage, irrespective of study setting. Principal coordinates analysis confirmed a cluster of common PCR-ribotypes among all cohorts. In conclusion, we identified dominant PCR-ribotypes common to geographically disparate Australian paediatric populations. Future genomic analyses will shed further light on the precise factors underlying the dominance of certain NTHi strains in nasopharyngeal carriage.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10919
DOI: 10.1186/s41479-016-0013-y
ISSN: 2200-6133
Type: Journal Article
Subjects: Carriage
Genotyping
Non-typeable Haemophilus influenzae
PCR-ribotyping
Paediatric
Appears in Collections:NT Health digital library

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.