Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/10922
Title: Pregnancy And Neonatal Diabetes Outcomes in Remote Australia: the PANDORA study-an observational birth cohort.
Authors: Maple-Brown, Louise
Lee, I-Lynn
Longmore, Danielle
Barzi, Federica
Connors, Christine
Boyle, Jacqueline A
Moore, Elizabeth
Whitbread, Cherie
Kirkwood, Marie
Graham, Sian
Hampton, Vanya
Simmonds, Alison
Van Dokkum, Paula
Kelaart, Joanna
Thomas, Sujatha
Chitturi, Shridhar
Eades, Sandra
Corpus, Sumaria
Lynch, Michael
Lu, Zhong X
O'Dea, Kerin
Zimmet, Paul
Oats, Jeremy
McIntyre, Harold D
Brown, Alex D H
Shaw, Jonathan E
Affiliation: Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, NT, Australia.. Endocrinology Department, Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia..
Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, NT, Australia..
Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, NT, Australia..
Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, NT, Australia..
Remote Primary Health Care, Top End Health Services, Northern Territory Department of Health, Darwin, NT, Australia..
Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, NT, Australia.. Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia..
Public Health Unit, Aboriginal Medical Services Alliance, Darwin, NT, Australia..
Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, NT, Australia.. Endocrinology Department, Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia..
Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, NT, Australia..
Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, NT, Australia..
Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, NT, Australia..
Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, NT, Australia..
Aboriginal Health Domain, Baker Heart and Diabetes Institute, Alice Springs, NT, Australia..
Aboriginal Health Domain, Baker Heart and Diabetes Institute, Alice Springs, NT, Australia..
Division of Maternal and Child Health, Royal Darwin Hospital, Darwin, NT, Australia..
Endocrinology Department, Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia..
Clinical and Population Health, Baker Heart and Diabetes Institute, Melbourne, Australia..
Clinical Services, Danila Dilba Health Service, Darwin, NT, Australia..
Pathology Network, Top End Health and Hospital Services, Darwin, NT, Australia..
Biochemistry Department, Melbourne Pathology, Melbourne, VIC, Australia.. Department of Medicine, Monash University, Melbourne, Australia..
Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, NT, Australia.. School of Health Sciences, University of South Australia, Adelaide, SA, Australia..
Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia..
Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia..
Faculty of Medicine, Mater Medical Research Institute, University of Queensland, Brisbane, QLD, Australia..
Wardliparingga Aboriginal Research Unit, South Australian Health and Medical Research Institute, Adelaide, SA, Australia..
Clinical and Population Health, Baker Heart and Diabetes Institute, Melbourne, Australia..
Issue Date: 30-Nov-2018
Citation: International journal of epidemiology 2018-11-30
Abstract: In Australia's Northern Territory, 33% of babies are born to Indigenous mothers, who experience high rates of hyperglycemia in pregnancy. We aimed to determine the extent to which pregnancy outcomes for Indigenous Australian women are explained by relative frequencies of diabetes type [type 2 diabetes (T2DM) and gestational diabetes (GDM)]. This prospective birth cohort study examined participants recruited from a hyperglycemia in pregnancy register. Baseline data collected were antenatal and perinatal clinical information, cord blood and neonatal anthropometry. Of 1135 women (48% Indigenous), 900 had diabetes: 175 T2DM, 86 newly diagnosed diabetes in pregnancy (DIP) and 639 had GDM. A group of 235 women without hyperglycemia in pregnancy was also recruited. Diabetes type differed for Indigenous and non-Indigenous women (T2DM, 36 vs 5%; DIP, 15 vs 7%; GDM, 49 vs 88%, p < 0.001). Within each diabetes type, Indigenous women were younger and had higher smoking rates. Among women with GDM/DIP, Indigenous women demonstrated poorer birth outcomes than non-Indigenous women: large for gestational age, 19 vs 11%, p = 0·002; neonatal fat 11.3 vs 10.2%, p < 0.001. In the full cohort, on multivariate regression, T2DM and DIP were independently associated (and Indigenous ethnicity was not) with pregnancy outcomes. Higher rates of T2DM among Indigenous women predominantly contribute to absolute poorer pregnancy outcomes among Indigenous women with hyperglycemia. As with Indigenous and minority populations globally, prevention or delay of type 2 diabetes in younger women is vital to improve pregnancy outcomes and possibly to improve the long-term health of their offspring.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/10922
DOI: 10.1093/ije/dyy245
Type: Journal Article
Appears in Collections:NT Health digital library

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