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Title: Influenza epidemiology, vaccine coverage and vaccine effectiveness in sentinel Australian hospitals in 2013: the Influenza Complications Alert Network.
Authors: Cheng, Allen C
Dwyer, Dominic E
Holmes, Mark
Irving, Lois B
Brown, Simon Ga
Waterer, Grant W
Korman, Tony M
Hunter, Cameron
Hewagama, Saliya
Friedman, Nadia D
Wark, Peter A
Simpson, Graham
Upham, John W
Bowler, Simon D
Senenayake, Sanjaya N
Kotsimbos, Tom C
Kelly, Paul M
Affiliation: Alfred Health; Monash University, Melbourne, Victoria..
University of Sydney, Sydney, New South Wales and Westmead Hospital, Sydney, New South Wales..
Royal Adelaide Hospital, Adelaide, South Australia and University of Adelaide, Adelaide, South Australia..
Royal Melbourne Hospital, Melbourne, Victoria and University of Melbourne, Melbourne, Victoria..
University of Western Australia, Perth, Western Australia and Royal Perth Hospital, Perth, Western Australia..
University of Western Australia, Perth, Western Australia and Royal Perth Hospital, Perth, Western Australia..
Monash Medical Centre, Melbourne, Victoria..
Royal Hobart Hospital, Hobart, Tasmania..
Alice Springs Hospital, Alice Springs, Northern Territory..
Barwon Health, Geelong, Victoria..
University of Newcastle, Newcastle, New South Wales and John Hunter Hospital, Newcastle, New South Wale..
Cairns Base Hospital, Cairns, Queensland..
Princess Alexandra Hospital, Brisbane, Queensland and University of Queensland, Brisbane, Queensland..
Mater Hospitals, Brisbane, Queensland..
Australian National University, Acton, Australian Capital Territor and The Canberra Hospital, Garran, Australian Capital Territory..
Alfred Health; Monash University, Melbourne, Victoria..
ACT Health Directorate, Canberra, Australian Capital Territory..
Issue Date: 30-Jun-2014
Citation: Communicable diseases intelligence quarterly report 2014-06-30; 38(2): E143-9
Abstract: The National Influenza Program aims to reduce serious morbidity and mortality from influenza by providing public funding for vaccination to at-risk groups. The Influenza Complications Alert Network (FluCAN) is a sentinel hospital-based surveillance program that operates at 14 sites in all states and territories in Australia. This report summarises the epidemiology of hospitalisations with confirmed influenza, estimates vaccine coverage and influenza vaccine protection against hospitalisation with influenza during the 2013 influenza season. In this observational study, cases were defined as patients admitted to one of the sentinel hospitals, with influenza confirmed by nucleic acid testing. Controls were patients who had acute respiratory illnesses who were test-negative for influenza. Vaccine effectiveness was estimated as 1 minus the odds ratio of vaccination in case patients compared with control patients, after adjusting for known confounders. During the period 5 April to 31 October 2012, 631 patients were admitted with confirmed influenza at the 14 FluCAN sentinel hospitals. Of these, 31% were more than 65 years of age, 9.5% were Indigenous Australians, 4.3% were pregnant and 77% had chronic co-morbidities. Influenza B was detected in 30% of patients. Vaccination coverage was estimated at 81% in patients more than 65 years of age but only 49% in patients aged less than 65 years with chronic comorbidities. Vaccination effectiveness against hospitalisation with influenza was estimated at 50% (95% confidence interval: 33%, 63%, P<0.001). We detected a significant number of hospital admissions with confirmed influenza in a national observational study. Vaccine coverage was incomplete in at-risk groups, particularly non-elderly patients with medical comorbidities. Our results suggest that the seasonal influenza vaccine was moderately protective against hospitalisation with influenza in the 2013 season.
ISSN: 1447-4514
Type: Historical Article
Journal Article
Subjects: Adolescent
Aged, 80 and over
History, 21st Century
Influenza Vaccines
Influenza, Human
Middle Aged
Patient Outcome Assessment
Risk Factors
Severity of Illness Index
Young Adult
Sentinel Surveillance
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