Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/11067
Title: Assessment of renal functional maturation and injury in preterm neonates during the first month of life.
Authors: Gubhaju, Lina
Sutherland, Megan R
Horne, Rosemary S C
Medhurst, Alison
Kent, Alison L
Ramsden, Andrew
Moore, Lynette
Singh, Gurmeet
Hoy, Wendy E
Black, M Jane
Affiliation: Preventative Health, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia;.
Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia;.
Ritchie Centre for Baby Health Research, Monash Institute of Medical Research, Clayton, Victoria, Australia;.
Monash Newborn, Monash Medical Centre, Clayton, Victoria, Australia;.
Department of Neonatology, Canberra Hospital, and the Australian National University Medical School, Canberra, Australian Capital Territory, Australia;.
Monash Newborn, Monash Medical Centre, Clayton, Victoria, Australia;.
Department of Surgical Pathology, South Australia Pathology, Women's and Children's Hospital, North Adelaide and the University of Adelaide, Adelaide, South Australia, Australia;.
Menzies School of Health Research and the Royal Darwin Hospital, Casuarina, Northern Territory, Australia; and..
Centre for Chronic Disease, University of Queensland, Brisbane, Queensland, Australia..
Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia; Jane.Black@monash.edu..
Issue Date: 15-Jul-2014
Citation: American journal of physiology. Renal physiology 2014-07-15; 307(2): F149-58
Abstract: Worldwide, approximately 10% of neonates are born preterm. The majority of preterm neonates are born when the kidneys are still developing; therefore, during the early postnatal period renal function is likely reflective of renal immaturity and/or injury. This study evaluated glomerular and tubular function and urinary neutrophil gelatinase-associated lipocalin (NGAL; a marker of renal injury) in preterm neonates during the first month of life. Preterm and term infants were recruited from Monash Newborn (neonatal intensive care unit at Monash Medical Centre) and Jesse McPherson Private Hospital, respectively. Infants were grouped according to gestational age at birth: ≤28 wk (n = 33), 29-31 wk (n = 44), 32-36 wk (n = 32), and term (≥37 wk (n = 22)). Measures of glomerular and tubular function were assessed on postnatal days 3-7, 14, 21, and 28. Glomerular and tubular function was significantly affected by gestational age at birth, as well as by postnatal age. By postnatal day 28, creatinine clearance remained significantly lower among preterm neonates compared with term infants; however, sodium excretion was not significantly different. Pathological proteinuria and high urinary NGAL levels were observed in a number of neonates, which may be indicative of renal injury; however, there was no correlation between the two markers. Findings suggest that neonatal renal function is predominantly influenced by renal maturity, and there was high capacity for postnatal tubular maturation among preterm neonates. There is insufficient evidence to suggest that urinary NGAL is a useful marker of renal injury in the preterm neonate.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/11067
DOI: 10.1152/ajprenal.00439.2013
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: preterm birth
proteinuria
renal development
renal injury
Acute Kidney Injury
Acute-Phase Proteins
Age Factors
Biomarkers
Creatinine
Gestational Age
Glomerular Filtration Rate
Humans
Infant, Extremely Premature
Infant, Newborn
Kidney Glomerulus
Kidney Tubules
Lipocalin-2
Lipocalins
Models, Biological
Proteinuria
Proto-Oncogene Proteins
Victoria
Infant, Premature
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