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Title: Reduction in Staphylococcus aureus bacteraemia rates in patients receiving haemodialysis following alteration of skin antisepsis procedures.
Authors: Stewart, B J
Gardiner, T
Perry, G J
Tong, S Y C
Affiliation: Department of Nephrology, Royal Darwin Hospital, Darwin, Australia; Division of Medical Sciences, University of Oxford, Oxford, UK..
Infection Prevention and Management Unit, Royal Darwin Hospital, Darwin, Australia; Infection Control Unit, Queen Elizabeth II Hospital, Brisbane, Australia..
Department of Nephrology, Royal Darwin Hospital, Darwin, Australia; Department of Nephrology, Royal Perth Hospital, Perth, Australia..
Menzies School of Health Research, Darwin, Australia. Electronic address:
Issue Date: Feb-2016
Citation: The Journal of hospital infection 2016-02; 92(2): 191-3
Abstract: This study examined all cases of Staphylococcus aureus bacteraemia (SAB) in the haemodialysis cohort at the Royal Darwin Hospital, Australia over a seven-year period. Midway through this period, antisepsis for arteriovenous fistulae (AVF) and central venous catheters (CVC) changed from 0.5% chlorhexidine solution to 2% chlorhexidine solution. Rates of SAB episodes were calculated using registry data. Trends in SAB over time were analysed using an interrupted regression analysis. Following the change to 2% chlorhexidine, average SAB rates decreased by 68%, and it is estimated that 0.111 cases of SAB/patient-year were prevented. CVC-related SAB rates remained low throughout. These results support the use of 2% chlorhexidine in skin antisepsis for patients with AVF.
DOI: 10.1016/j.jhin.2015.10.022
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: ANZDATA
Arteriovenous fistula
Central venous catheter
Staphylococcus aureus
Anti-Infective Agents, Local
Catheter-Related Infections
Renal Dialysis
Retrospective Studies
Staphylococcal Infections
Staphylococcus aureus
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