Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/11254
Title: Differential association of C-reactive protein with adiposity in men and women in an Aboriginal community in northeast Arnhem Land of Australia.
Authors: Shemesh, T
Rowley, K G
Jenkins, A
Brimblecombe, J
Best, J D
O'Dea, K
Affiliation: Menzies School of Health Research, Royal Darwin Hospital, Rocklands Drive Tiwi, Northern Territory, Australia. tomers@medstv.unimelb.edu.au.
Issue Date: Jan-2007
Citation: International journal of obesity (2005) 2007-01; 31(1): 103-8
Abstract: To examine the relationship between C-reactive protein (CRP), adiposity and other metabolic abnormalities in an Aboriginal community in Northern Australia. Cross-sectional analysis of data obtained between 2001 and 2003 from 379 Aboriginal people residing in a geographically isolated community. Mean (95% CI) CRP in women and men was 4.06 cholesterol (3.53, 4.66) mg/l and 3.42 (2.94, 3.97) mg/l, respectively (P=NS). The prevalence of the metabolic syndrome (US National Cholesterol Education [corrected] Program (NCEP) definition) was significantly higher for women than men (41 vs 18%, chi (2)=20.94, P<0.001). C-reactive protein correlated strongly with adiposity in women (waist circumference, waist to hip ratio and body mass index; r>/=0.514, P<0.01) but much less strongly in men (r</=0.221, P<0.05). In a multivariate stepwise linear regression model, waist circumference was the strongest independent predictor explaining 35% of CRP concentration variance in women, but only 5.4% in men (WHR). Incremental increases in CRP concentration across four BMI categories were significant in women (P (linear trend)<0.001) but not in men. High CRP levels in the surveyed population are consistent with the high prevalence of vascular disease morbidity and mortality in Aboriginal Australians. The relationship of CRP with increasing body fat was strong and consistent in women but not in men. Prospective studies are needed to elucidate the role of CRP (if any) as a predictive marker for cardiovascular events in this high-risk population.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/11254
DOI: 10.1038/sj.ijo.0803350
ISSN: 0307-0565
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: Adipose Tissue
Adult
Body Mass Index
Body Size
C-Reactive Protein
Cardiovascular Diseases
Cross-Sectional Studies
Female
Humans
Male
Metabolic Syndrome
Northern Territory
Obesity
Population Surveillance
Prevalence
Risk Factors
Sex Distribution
Oceanic Ancestry Group
Appears in Collections:NT Health digital library

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