Please use this identifier to cite or link to this item: http://docs.prosentient.com.au/prosentientjspui/handle/1/11273
Title: Greater endothelial activation, Weibel-Palade body release and host inflammatory response to Plasmodium vivax, compared with Plasmodium falciparum: a prospective study in Papua, Indonesia.
Authors: Yeo, Tsin W
Lampah, Daniel A
Tjitra, Emiliana
Piera, Kim
Gitawati, Retno
Kenangalem, Enny
Price, Ric N
Anstey, Nicholas M
Affiliation: International Health Division, Menzies School of Health Research and Charles Darwin University, and Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia..
Issue Date: 1-Jul-2010
Citation: The Journal of infectious diseases 2010-07-01; 202(1): 109-12
Abstract: Pathogenic mechanisms underlying vivax malaria are poorly understood, with few studies comparing endothelial and inflammatory responses with falciparum malaria. In adults with uncomplicated vivax or falciparum malaria, we compared plasma measurements of endothelial Weibel-Palade body release (angiopoietin-2) and activation (ICAM-1, E-selectin), as well as selected cytokines. Despite a lower median parasite count, angiopoietin-2 concentrations were higher in patients with vivax malaria, compared with falciparum malaria. Per peripheral parasite, median plasma angiopoietin-2, ICAM-1, E-selectin, interleukin-6, and interleukin-10 concentrations were higher in patients with malaria due to Plasmodium vivax. P. vivax induces greater endothelial Weibel-Palade body release and activation and greater host inflammatory responses, compared with Plasmodium falciparum.
URI: http://docs.prosentient.com.au/prosentientjspui/handle/1/11273
DOI: 10.1086/653211
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: Animals
E-Selectin
Gene Expression Regulation
Humans
Indonesia
Inflammation
Intercellular Adhesion Molecule-1
Interleukin-10
Interleukin-6
Malaria, Falciparum
Malaria, Vivax
Plasmodium falciparum
Plasmodium vivax
Weibel-Palade Bodies
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