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Title: The burden of invasive infections in critically ill Indigenous children in Australia.
Authors: Ostrowski, Justyna A
MacLaren, Graeme
Alexander, Janet
Stewart, Penny
Gune, Sheena
Francis, Joshua R
Ganu, Subodh
Festa, Marino
Erickson, Simon J
Straney, Lahn
Schlapbach, Luregn J
Affiliation: Mater Research Institute, University of Queensland, Brisbane, QLD
University of Melbourne, Melbourne, VIC..
Australian and New Zealand Paediatric Intensive Care Registry (CORE), Brisbane, QLD..
Alice Springs Hospital, Alice Springs, NT..
Alice Springs Hospital, Alice Springs, NT..
Royal Darwin Hospital, Darwin, NT..
Women's and Children's Hospital Adelaide, Adelaide, SA..
Children's Hospital at Westmead, Sydney, NSW..
Princess Margaret Hospital for Children, Perth, WA..
Monash University, Melbourne, VIC..
Mater Research Institute, University of Queensland, Brisbane, QLD..
Issue Date: 6-Feb-2017
Citation: The Medical journal of Australia 2017-02-06; 206(2): 78-84
Abstract: To describe the incidence and mortality of invasive infections in Indigenous children admitted to paediatric and general intensive care units (ICUs) in Australia. Retrospective multi-centre cohort study of Australian and New Zealand Paediatric Intensive Care Registry data. All children under 16 years of age admitted to an ICU in Australia, 1 January 2002 - 31 December 2013. Indigenous children were defined as those identified as Aboriginal and/or Torres Strait Islander in a mandatory admissions dataset. Population-based ICU mortality and admission rates. Invasive infections accounted for 23.0% of non-elective ICU admissions of Indigenous children (726 of 3150), resulting in an admission rate of 47.6 per 100 000 children per year. Staphylococcus aureus was the leading pathogen identified in children with sepsis/septic shock (incidence, 4.42 per 100 000 Indigenous children per year; 0.57 per 100 000 non-Indigenous children per year; incidence rate ratio 7.7; 95% CI, 5.8-10.1; P < 0.001). While crude and risk-adjusted ICU mortality related to invasive infections was not significantly different for Indigenous and non-Indigenous children (odds ratio, 0.75; 95% CI, 0.53-1.07; P = 0.12), the estimated population-based age-standardised mortality rate for invasive infections was significantly higher for Indigenous children (2.67 per 100 000 per year v 1.04 per 100 000 per year; crude incidence rate ratio, 2.65; 95% CI, 1.88-3.64; P < 0.001). The ICU admission rate for severe infections was several times higher for Indigenous than for non-Indigenous children, particularly for S. aureus infections. While ICU case fatality rates were similar, the population-based mortality was more than twice as high for Indigenous children. Our study highlights an important area of inequality in health care for Indigenous children in a high income country that needs urgent attention.
Type: Journal Article
Subjects: Adolescent
Child, Hospitalized
Child, Preschool
Cohort Studies
Critical Care Outcomes
Critical Illness
Healthcare Disparities
Infant, Newborn
Intensive Care Units
New Zealand
Population Groups
Retrospective Studies
Severity of Illness Index
Staphylococcal Infections
Staphylococcus aureus
Survival Analysis
Cost of Illness
Appears in Collections:NT Health digital library

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