Please use this identifier to cite or link to this item:
|Title:||A neuroligin-3 mutation implicated in autism causes abnormal aggression and increases repetitive behavior in mice|
|Authors:||Bornstein, Joel C|
Burrows, Emma L
Hannan, Anthony J
Hill-Yardin, Elisa L
|Publication information:||Molecular Autism 2015, vol. 6 p. 52|
|Abstract:||The presence of aberrant aggression and other behavioral phenotypes in NL3(R451C) mice consistent with clinical traits strengthen face validity of this model of ASD. Furthermore, we demonstrate predictive validity in this model through the reversal of the aggressive phenotype with risperidone. This is the first demonstration that risperidone can ameliorate aggression in an animal model of ASD and will inform mechanistic and therapeutic research into the neurobiology underlying abnormal behaviors in ASD.|
|Appears in Collections:||Training submission area|
Files in This Item:
There are no files associated with this item.
Items in the Prosentient are protected by copyright, with all rights reserved, unless otherwise indicated.