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Title: A neuroligin-3 mutation implicated in autism causes abnormal aggression and increases repetitive behavior in mice
Authors: Bornstein, Joel C
Burrows, Emma L
Churilov, Leonid
Hannan, Anthony J
Hill-Yardin, Elisa L
Koyama, Lynn
Laskaris, Liliana
Citation: Molecular Autism 2015, vol. 6 p. 52
Abstract: The presence of aberrant aggression and other behavioral phenotypes in NL3(R451C) mice consistent with clinical traits strengthen face validity of this model of ASD. Furthermore, we demonstrate predictive validity in this model through the reversal of the aggressive phenotype with risperidone. This is the first demonstration that risperidone can ameliorate aggression in an animal model of ASD and will inform mechanistic and therapeutic research into the neurobiology underlying abnormal behaviors in ASD.
metadata.dc.identifier.doi: 10.1186/s13229-015-0055-7
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